The effect of carboxylate groups on the complexation of metal ion with oligopeptides – Potentiometric investigation

Norbert Lihi, Márton Lukács, Mária Raics, Györgyi Szunyog, K. Várnagy, C. Kállay

Research output: Contribution to journalArticle

Abstract

Iron(II), iron(III), cobalt(II), zinc(II) cadmium(II) and lead(II) complexes of Asp2 and Asp3 and other Asp/Glu containing ligands were studied by potentiometry. Our goal was to study the influence of β- and γ-carboxylate groups as well as the increased negative charge of the ligands on the complex formation processes. Mainly 1:1 species are present, the formation of bis(ligand) complexes is not typical for these systems. It can be concluded that the effect of side chain carboxylate groups on the stability of complexes is especially significant in the case of lead(II) and cadmium(II). The greater the number of carboxylic groups there are in the system, the more stable complexes are formed with the studied metal ions. The influence of β-carboxylate groups of aspartic acid is unambiguous, they are directly bounded to the metal ion, which results in increased stability of the complexes. On the other hand, the repulsion between the negative charged residues becomes conspicuous resulting less stable species in the case of peptides containing glutamic acid.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalInorganica Chimica Acta
Volume472
DOIs
Publication statusPublished - Mar 1 2018

Fingerprint

Oligopeptides
Complexation
carboxylates
Metal ions
metal ions
Ligands
Cadmium
Iron
Lead
cadmium
ligands
Acids
Cobalt
potentiometric analysis
iron
Aspartic Acid
aspartic acid
glutamic acid
Peptides
Zinc

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

The effect of carboxylate groups on the complexation of metal ion with oligopeptides – Potentiometric investigation. / Lihi, Norbert; Lukács, Márton; Raics, Mária; Szunyog, Györgyi; Várnagy, K.; Kállay, C.

In: Inorganica Chimica Acta, Vol. 472, 01.03.2018, p. 165-173.

Research output: Contribution to journalArticle

@article{741b3cd9196447f1b327c5cf78426047,
title = "The effect of carboxylate groups on the complexation of metal ion with oligopeptides – Potentiometric investigation",
abstract = "Iron(II), iron(III), cobalt(II), zinc(II) cadmium(II) and lead(II) complexes of Asp2 and Asp3 and other Asp/Glu containing ligands were studied by potentiometry. Our goal was to study the influence of β- and γ-carboxylate groups as well as the increased negative charge of the ligands on the complex formation processes. Mainly 1:1 species are present, the formation of bis(ligand) complexes is not typical for these systems. It can be concluded that the effect of side chain carboxylate groups on the stability of complexes is especially significant in the case of lead(II) and cadmium(II). The greater the number of carboxylic groups there are in the system, the more stable complexes are formed with the studied metal ions. The influence of β-carboxylate groups of aspartic acid is unambiguous, they are directly bounded to the metal ion, which results in increased stability of the complexes. On the other hand, the repulsion between the negative charged residues becomes conspicuous resulting less stable species in the case of peptides containing glutamic acid.",
author = "Norbert Lihi and M{\'a}rton Luk{\'a}cs and M{\'a}ria Raics and Gy{\"o}rgyi Szunyog and K. V{\'a}rnagy and C. K{\'a}llay",
year = "2018",
month = "3",
day = "1",
doi = "10.1016/j.ica.2017.07.032",
language = "English",
volume = "472",
pages = "165--173",
journal = "Inorganica Chimica Acta",
issn = "0020-1693",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - The effect of carboxylate groups on the complexation of metal ion with oligopeptides – Potentiometric investigation

AU - Lihi, Norbert

AU - Lukács, Márton

AU - Raics, Mária

AU - Szunyog, Györgyi

AU - Várnagy, K.

AU - Kállay, C.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Iron(II), iron(III), cobalt(II), zinc(II) cadmium(II) and lead(II) complexes of Asp2 and Asp3 and other Asp/Glu containing ligands were studied by potentiometry. Our goal was to study the influence of β- and γ-carboxylate groups as well as the increased negative charge of the ligands on the complex formation processes. Mainly 1:1 species are present, the formation of bis(ligand) complexes is not typical for these systems. It can be concluded that the effect of side chain carboxylate groups on the stability of complexes is especially significant in the case of lead(II) and cadmium(II). The greater the number of carboxylic groups there are in the system, the more stable complexes are formed with the studied metal ions. The influence of β-carboxylate groups of aspartic acid is unambiguous, they are directly bounded to the metal ion, which results in increased stability of the complexes. On the other hand, the repulsion between the negative charged residues becomes conspicuous resulting less stable species in the case of peptides containing glutamic acid.

AB - Iron(II), iron(III), cobalt(II), zinc(II) cadmium(II) and lead(II) complexes of Asp2 and Asp3 and other Asp/Glu containing ligands were studied by potentiometry. Our goal was to study the influence of β- and γ-carboxylate groups as well as the increased negative charge of the ligands on the complex formation processes. Mainly 1:1 species are present, the formation of bis(ligand) complexes is not typical for these systems. It can be concluded that the effect of side chain carboxylate groups on the stability of complexes is especially significant in the case of lead(II) and cadmium(II). The greater the number of carboxylic groups there are in the system, the more stable complexes are formed with the studied metal ions. The influence of β-carboxylate groups of aspartic acid is unambiguous, they are directly bounded to the metal ion, which results in increased stability of the complexes. On the other hand, the repulsion between the negative charged residues becomes conspicuous resulting less stable species in the case of peptides containing glutamic acid.

UR - http://www.scopus.com/inward/record.url?scp=85026317980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026317980&partnerID=8YFLogxK

U2 - 10.1016/j.ica.2017.07.032

DO - 10.1016/j.ica.2017.07.032

M3 - Article

AN - SCOPUS:85026317980

VL - 472

SP - 165

EP - 173

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

SN - 0020-1693

ER -