The effect of capsaicin on afferent nerves and temperature regulation of mammals and birds

Fr K. Pierau, J. Szolcsányi, H. Sann

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

1. 1.|The impairment of nociception, warm reception and temperature regulation by capsaicin relates to the particular effect of the drug upon unmyelinated sensory nerve fibres which contain substance P and/or somatostatin. 2. 2.|Capsaicin also activates and subsequently desensitizes warm sensitive neurones in the hypothalamus, which contributes to impaired temperature regulation at high ambient temperatures. 3. 3.|Birds are highly insensitive to capsaicin. The threshold concentration for nociceptive reactions is about 1000-10,000 times that of mammals; temperature regulation was not impaired by doses up to 1 g/kg body weight. 4. 4.|The resistance of birds to capsaicin might be due to functional differences between mammals and birds in neuropeptide-containing neurones.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalJournal of Thermal Biology
Volume11
Issue number2
DOIs
Publication statusPublished - 1986

Fingerprint

capsaicin
Mammals
Capsaicin
Birds
nerve tissue
mammals
Temperature
birds
Neurons
temperature
neurons
nociception
Unmyelinated Nerve Fibers
substance P
somatostatin
Nociception
neuropeptides
nerve fibers
Substance P
hypothalamus

Keywords

  • Capsaicin
  • desensitization
  • hypothalamic neurones
  • nociception
  • sensory neurones
  • substance P
  • temperature reception
  • temperature regulation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

The effect of capsaicin on afferent nerves and temperature regulation of mammals and birds. / Pierau, Fr K.; Szolcsányi, J.; Sann, H.

In: Journal of Thermal Biology, Vol. 11, No. 2, 1986, p. 95-100.

Research output: Contribution to journalArticle

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