The effect of calyx infusion of Hibiscus sabdariffa L. on T-cells-mediated immune response in mitogen-induced blastogenesis of human lymphocytes in vitro

E. Rapavi, R. González-Cabello, K. Szentmihályi, E. Székely, A. Blázovics

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Free radical production and disturbance in the redox status may modulate the expression of a variety of immune and inflammatory molecules. Antioxidants could inhibit the proliferation of T lymphocytes induced by mitogens. The aim of this study was to investigate the effect of the infusion of dried calyx of Hibiscus sabdariffa L. on T-cell-mediated immune response. We examined the effect of the infusion on spontaneous and mitogen-induced blast transformation of human lymphocytes in vitro. Peripheral blood lymphocytes from heparinised venous blood of healthy subjects (n=17) were examined. Five and 10 □g ml-1 phytohemagglutinin (PHA) and 5 □g ml-1 pokeweed mitogen (PWM) were added. Depending on the concentration, calyx infusion of H. sabdariffa decreased mitogen-induced blastogenesis in normal subjects. It did not affect, however, the level of spontaneous proliferation of human lymphocytes in vitro. The infusion of hibisci flos may alleviate over-stimulated condition of the immune system in hypersensitivity conditions.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalActa Alimentaria
Volume35
Issue number3
DOIs
Publication statusPublished - 2006

Fingerprint

Hibiscus
Hibiscus sabdariffa
lymphocyte proliferation
Lymphocyte Activation
calyx
Mitogens
cell-mediated immunity
lymphocytes
T-lymphocytes
Lymphocytes
T-Lymphocytes
Pokeweed Mitogens
Phytolacca americana
phytohemagglutinin
blood
Phytohemagglutinins
hypersensitivity
Oxidation-Reduction
Free Radicals
immune system

Keywords

  • Antioxidants
  • Blast transformation
  • Hibiscus sabdariffa L.
  • Polyphenols

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

The effect of calyx infusion of Hibiscus sabdariffa L. on T-cells-mediated immune response in mitogen-induced blastogenesis of human lymphocytes in vitro. / Rapavi, E.; González-Cabello, R.; Szentmihályi, K.; Székely, E.; Blázovics, A.

In: Acta Alimentaria, Vol. 35, No. 3, 2006, p. 281-288.

Research output: Contribution to journalArticle

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