The effect of caffeine on cell cycle progression and polar growth in Schizosaccharomyces pombe

Matthias Sipigzki, Kanji Takeo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of 8 to 13 m M caffeine on cell cycle progression and the growth pattern of Schizosaccharomyces pombe cells exponentially growing in liquid cultures was studied. The drug was found to dramatically increase the length of the cell cycle by interfering with the nuclear cycle. Since cell extension was less severely affected, the reduction of the propagation rate resulted in an increase of cell length. The longer cells grew unipolarly, suggesting that the most sensitive target of caffeine must be in the pre-NETO part of the cell cycle.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalBiologia
Volume53
Issue number3
Publication statusPublished - Dec 1 1998

Keywords

  • Caffeine
  • Cell cycle
  • Fission yeast
  • Polar growth

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Animal Science and Zoology
  • Molecular Biology
  • Genetics
  • Plant Science
  • Cell Biology

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