The effect of bright light exposure on pupillary fluctuations in healthy subjects

Zoltán Szabó, Zsolt Tokaji, J. Kálmán, László Oroszi, Anikó Pestenácz, Z. Janka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Light therapy is thought to be the first choice treatment of winter depression. However, its way of action is poorly understood. In order to find a solid effect of bright artificial light, we studied its possible alerting action through the spontaneous fluctuations of the pupil, considered to be an objective measurement of vigilance. Methods: Pupillary fluctuations of 10 healthy subjects (mean age: 22±1 S.D. years) were measured for 60 s before and 15 min after 0.5 h, 10 000-lux light exposure. The cumulative change in pupil size, characterised by the pupillary unrest index (PUI) decreased at each subject, and this decrease was in average 35±4.4% S.E.M. The average pupillary diameters were unchanged (101±2.2% S.E.M.). This analysis revealed that the slow components of the pupillary fluctuations also decreased considerably. Limitations: There was no dim light or other placebo control of the light treatment. Conclusions: Bright light exposure significantly influenced the pupillary fluctuations. We suppose that bright light exposure increases the level of alertness, and this could be a possible way by which bright artificial light exerts a beneficial effect also in affective disorders.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalJournal of Affective Disorders
Volume78
Issue number2
DOIs
Publication statusPublished - Feb 2004

Fingerprint

Healthy Volunteers
Light
Pupil
Phototherapy
Mood Disorders
Placebos
Depression
Therapeutics

Keywords

  • Alertness
  • Pupillary oscillation
  • Pupillography
  • Seasonal affective disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

The effect of bright light exposure on pupillary fluctuations in healthy subjects. / Szabó, Zoltán; Tokaji, Zsolt; Kálmán, J.; Oroszi, László; Pestenácz, Anikó; Janka, Z.

In: Journal of Affective Disorders, Vol. 78, No. 2, 02.2004, p. 153-156.

Research output: Contribution to journalArticle

Szabó, Zoltán ; Tokaji, Zsolt ; Kálmán, J. ; Oroszi, László ; Pestenácz, Anikó ; Janka, Z. / The effect of bright light exposure on pupillary fluctuations in healthy subjects. In: Journal of Affective Disorders. 2004 ; Vol. 78, No. 2. pp. 153-156.
@article{9d2071ad51ef4ab688e5c175e74b328f,
title = "The effect of bright light exposure on pupillary fluctuations in healthy subjects",
abstract = "Background: Light therapy is thought to be the first choice treatment of winter depression. However, its way of action is poorly understood. In order to find a solid effect of bright artificial light, we studied its possible alerting action through the spontaneous fluctuations of the pupil, considered to be an objective measurement of vigilance. Methods: Pupillary fluctuations of 10 healthy subjects (mean age: 22±1 S.D. years) were measured for 60 s before and 15 min after 0.5 h, 10 000-lux light exposure. The cumulative change in pupil size, characterised by the pupillary unrest index (PUI) decreased at each subject, and this decrease was in average 35±4.4{\%} S.E.M. The average pupillary diameters were unchanged (101±2.2{\%} S.E.M.). This analysis revealed that the slow components of the pupillary fluctuations also decreased considerably. Limitations: There was no dim light or other placebo control of the light treatment. Conclusions: Bright light exposure significantly influenced the pupillary fluctuations. We suppose that bright light exposure increases the level of alertness, and this could be a possible way by which bright artificial light exerts a beneficial effect also in affective disorders.",
keywords = "Alertness, Pupillary oscillation, Pupillography, Seasonal affective disorder",
author = "Zolt{\'a}n Szab{\'o} and Zsolt Tokaji and J. K{\'a}lm{\'a}n and L{\'a}szl{\'o} Oroszi and Anik{\'o} Pesten{\'a}cz and Z. Janka",
year = "2004",
month = "2",
doi = "10.1016/S0165-0327(02)00241-0",
language = "English",
volume = "78",
pages = "153--156",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - The effect of bright light exposure on pupillary fluctuations in healthy subjects

AU - Szabó, Zoltán

AU - Tokaji, Zsolt

AU - Kálmán, J.

AU - Oroszi, László

AU - Pestenácz, Anikó

AU - Janka, Z.

PY - 2004/2

Y1 - 2004/2

N2 - Background: Light therapy is thought to be the first choice treatment of winter depression. However, its way of action is poorly understood. In order to find a solid effect of bright artificial light, we studied its possible alerting action through the spontaneous fluctuations of the pupil, considered to be an objective measurement of vigilance. Methods: Pupillary fluctuations of 10 healthy subjects (mean age: 22±1 S.D. years) were measured for 60 s before and 15 min after 0.5 h, 10 000-lux light exposure. The cumulative change in pupil size, characterised by the pupillary unrest index (PUI) decreased at each subject, and this decrease was in average 35±4.4% S.E.M. The average pupillary diameters were unchanged (101±2.2% S.E.M.). This analysis revealed that the slow components of the pupillary fluctuations also decreased considerably. Limitations: There was no dim light or other placebo control of the light treatment. Conclusions: Bright light exposure significantly influenced the pupillary fluctuations. We suppose that bright light exposure increases the level of alertness, and this could be a possible way by which bright artificial light exerts a beneficial effect also in affective disorders.

AB - Background: Light therapy is thought to be the first choice treatment of winter depression. However, its way of action is poorly understood. In order to find a solid effect of bright artificial light, we studied its possible alerting action through the spontaneous fluctuations of the pupil, considered to be an objective measurement of vigilance. Methods: Pupillary fluctuations of 10 healthy subjects (mean age: 22±1 S.D. years) were measured for 60 s before and 15 min after 0.5 h, 10 000-lux light exposure. The cumulative change in pupil size, characterised by the pupillary unrest index (PUI) decreased at each subject, and this decrease was in average 35±4.4% S.E.M. The average pupillary diameters were unchanged (101±2.2% S.E.M.). This analysis revealed that the slow components of the pupillary fluctuations also decreased considerably. Limitations: There was no dim light or other placebo control of the light treatment. Conclusions: Bright light exposure significantly influenced the pupillary fluctuations. We suppose that bright light exposure increases the level of alertness, and this could be a possible way by which bright artificial light exerts a beneficial effect also in affective disorders.

KW - Alertness

KW - Pupillary oscillation

KW - Pupillography

KW - Seasonal affective disorder

UR - http://www.scopus.com/inward/record.url?scp=0347052801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347052801&partnerID=8YFLogxK

U2 - 10.1016/S0165-0327(02)00241-0

DO - 10.1016/S0165-0327(02)00241-0

M3 - Article

VL - 78

SP - 153

EP - 156

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 2

ER -