The effect of aspartame administration on oncogene and suppressor gene expressions

Katalin Gombos, Tímea Varjas, Zsuzsanna Orsós, Éva Polyák, Judit Peredi, Zsuzsanna Varga, Ghodratollah Nowrasteh, Antal Tettinger, Gyula Mucsi, István Ember

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8 Citations (Scopus)


Background: Aspartame (L-phenylalanine N-L-α-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours occurred. The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene. Materials and Methods: After one week per os administration of various doses of aspartame to CBA/CA female mice, p53, c-myc, Ha-ras gene expression alterations were determined in individual organs. Results: The results showed an increase in gene expressions concerning all the investigated genes especially in organs with a high proliferation rate: lymphoreticular organs, bone-marrow and kidney. Conclusion: Aspartame has a biological effect even at the recommended daily maximum dose.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalIn Vivo
Issue number1
Publication statusPublished - Jan 1 2007



  • Artificial sweetener
  • Aspartame
  • Biological effect
  • Onco- and suppressor gene expression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Gombos, K., Varjas, T., Orsós, Z., Polyák, É., Peredi, J., Varga, Z., Nowrasteh, G., Tettinger, A., Mucsi, G., & Ember, I. (2007). The effect of aspartame administration on oncogene and suppressor gene expressions. In Vivo, 21(1), 89-92.