The effect of antidiuretic hormone, indomethacin and naproxen on prostaglandin synthesis of experimentally infected and healthy kidneys

S. Túri, M. Pulkkinen, Hanna Leena Kaihola, L. Kangas, L. Nieminen

Research output: Contribution to journalArticle

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Abstract

The authors studied the effect of indomethacin and naproxen on the changes of renal prostaglandin E and F2 alpha concentration in experimental kidney infection, as well as the action of arginine-vasopressin in healthy rats. Naproxen proved to be an effective inhibitor of prostaglandin synthesis, as did indomethacin. In control animals an increased prostaglandin E and F2 alpha synthesis was observed caused by arginine vasopressin. It is supposed that ADH - depending on its concentration - has a metabolic modulator role in prostaglandin synthesis, which raises the possibility of a self-regulatory mechanism of water reabsorption.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalInternational Urology and Nephrology
Volume14
Issue number3
DOIs
Publication statusPublished - Sep 1982

Fingerprint

Naproxen
Dinoprost
Arginine Vasopressin
Prostaglandins E
Vasopressins
Indomethacin
Prostaglandins
Kidney
Prostaglandin Antagonists
Water
Infection

ASJC Scopus subject areas

  • Urology
  • Nephrology
  • Geriatrics and Gerontology

Cite this

The effect of antidiuretic hormone, indomethacin and naproxen on prostaglandin synthesis of experimentally infected and healthy kidneys. / Túri, S.; Pulkkinen, M.; Kaihola, Hanna Leena; Kangas, L.; Nieminen, L.

In: International Urology and Nephrology, Vol. 14, No. 3, 09.1982, p. 195-200.

Research output: Contribution to journalArticle

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