The effect of antibiotic treatment on the in vivo selection of resistant haemolytic Escherichia coli clones in mice

Levente Emődy, Monika Kerényi, István Bátai

Research output: Contribution to journalArticle

Abstract

The appearance of resistant haemolytic Escherichia coli clones was studied in mice treated with a synergistic combination of antibiotics. The R plasmid donor and the haemolytic recipient were given orally. Ten animals were treated i.p. with 2.5 mg carbenicillin and 2.5 mg kanamycin pro die for 7 days. Ten control mice were injected with saline. Out of 80 faecal samples of animals receiving antibiotic treatment resistant haemolytic transconjugants were isolated from 13 samples by direct plating, and from 27 samples after selective enrichment. Out of 80 parallel samples of control animals a single one yielded a positive culture - after enrichment.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalFEMS microbiology letters
Volume22
Issue number3
Publication statusPublished - May 1984

Keywords

  • Escherichia coli
  • R plasmid transfer
  • antibiotic treatment
  • excretion of recombinants
  • haemolysin
  • in vivo selection

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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