The effect of anti lymphocyte and anti thymocyte serum on the pathogenesis of Rauscher leukaemia in inbred mouse strains

L. Vaczi, A. Leovey, F. Tóth, M. Kasa

Research output: Contribution to journalArticle

Abstract

Rauscher virus in inbred Balb/c mice causes a rapidly hyperacute leukemia in C57B1/10Sn mice an incipient, spontaneously healing leukemia. In DBA/1 and DBA/2 mice the appearance of leukemia is followed by a partial remission then by an exacerbation of the disease. The infection of C57B1/10Sn, DBA/1 and DBA/2 mice results in a significant tumor specific immune response. Inhibition of the immune response is followed by an increased progression of leukemia in DBA/1 and DBA/2 mice only. It is assumed that in C57B1/10Sn mice the remission of incipient leukemia is associated with a resistance determined in the target cells, whereas in DBA/1 and DBA/2 mice the remission is due to a tumor specific immune response. As in animals treated with anti lymphocyte and antithymocyte serum the course of the disease runs proportionally to the degree of the inhibition of the immune response, the tumor specific antibodies play a decisive role in the elimination of the tumor cells. In Balb/c, DBA/1 and DBA/2 mouse strains failing to exhibit a spontaneous reversion of the tumor cells, the appearance of a significant tumor specific immune response depends on the resistance against the helper component of the Rauscher virus complex.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalActa Microbiologica Academiae Scientiarum Hungaricae
Volume23
Issue number4
Publication statusPublished - 1976

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Inbred DBA Mouse
Inbred Strains Mice
Thymocytes
Leukemia
Lymphocytes
Rauscher Virus
Serum
Neoplasms
Neoplasm Antibodies
Disease Progression
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The effect of anti lymphocyte and anti thymocyte serum on the pathogenesis of Rauscher leukaemia in inbred mouse strains. / Vaczi, L.; Leovey, A.; Tóth, F.; Kasa, M.

In: Acta Microbiologica Academiae Scientiarum Hungaricae, Vol. 23, No. 4, 1976, p. 309-316.

Research output: Contribution to journalArticle

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