Az angiotenzinreceptor-blokkolók hatása agyi érbetegségekben és dementiában: Bónusz a vérnyomáscsökkentésen túl

Translated title of the contribution: The effect of angiotensin receptor blockers in cerebrovascular disorders and dementia: Bonus in addition to the antihypertensive effect

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hypertension and dementia are frequent disorders or rather syndromes. Their incidence is growing with advancing age and hypertension is increasing the risk of cognitive impairment too, while treating hypertension (i.e. the use of antihypertensive medications) is decreasing it. In addition, hypertension is the most important risk factor for stroke. The renin-angiotensin system (RAS) has a special role in the development of hypertension and also involved in the pathogenesis of the most frequent dementia form, namely Alzheimer's disease. The effect of angiotensin convertase inhibitors and angiotensin receptor blockers (ARB) is based on the inhibition of the RAS, but the ARBs do not inhibit angiotensin formation, just blocking its harmful effects on the AT1 receptor, while allowing the activation of AT2 receptors with pleiotropic effects. Preclinical, epidemiological and clinical therapeutic studies suggest this additional effect of ARBs and these are summarized in this review.

Original languageHungarian
Pages (from-to)149-168
Number of pages20
JournalIdeggyógyászati szemle
Volume67
Issue number5-6
Publication statusPublished - May 30 2014

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Cerebrovascular Disorders
Angiotensin Receptor Antagonists
Antihypertensive Agents
Dementia
Hypertension
Angiotensins
Renin-Angiotensin System
Alzheimer Disease
Stroke
Incidence

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

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title = "Az angiotenzinreceptor-blokkol{\'o}k hat{\'a}sa agyi {\'e}rbetegs{\'e}gekben {\'e}s dementi{\'a}ban: B{\'o}nusz a v{\'e}rnyom{\'a}scs{\"o}kkent{\'e}sen t{\'u}l",
abstract = "Hypertension and dementia are frequent disorders or rather syndromes. Their incidence is growing with advancing age and hypertension is increasing the risk of cognitive impairment too, while treating hypertension (i.e. the use of antihypertensive medications) is decreasing it. In addition, hypertension is the most important risk factor for stroke. The renin-angiotensin system (RAS) has a special role in the development of hypertension and also involved in the pathogenesis of the most frequent dementia form, namely Alzheimer's disease. The effect of angiotensin convertase inhibitors and angiotensin receptor blockers (ARB) is based on the inhibition of the RAS, but the ARBs do not inhibit angiotensin formation, just blocking its harmful effects on the AT1 receptor, while allowing the activation of AT2 receptors with pleiotropic effects. Preclinical, epidemiological and clinical therapeutic studies suggest this additional effect of ARBs and these are summarized in this review.",
keywords = "Alzheimer's disease, Angiotensin convertase inhibitors, Angiotensin receptor blockers, Dementia, Hypertension",
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KW - Angiotensin convertase inhibitors

KW - Angiotensin receptor blockers

KW - Dementia

KW - Hypertension

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