The effect of acute citalopram on face emotion processing in remitted depression: A pharmacoMRI study

Ian M. Anderson, Gabriella Juhasz, Emma Thomas, Darragh Downey, Shane McKie, J. F.William Deakin, Rebecca Elliott

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Both reduced serotonergic (5-HT) function and negative emotional biases have been associated with vulnerability to depression. In order to investigate whether these might be related we examined 5-HT modulation of affective processing in 14 remitted depressed subjects compared with 12 never depressed controls matched for age and sex. Participants underwent function magnetic resonance imaging (fMRI) during a covert face emotion task with and without intravenous citalopram (7.5. mg) pretreatment. Compared with viewing neutral faces, and irrespective of group, citalopram enhanced left anterior cingulate blood oxygen level dependent (BOLD) response to happy faces, right posterior insula and right lateral orbitofrontal responses to sad faces, and reduced amygdala responses bilaterally to fearful faces. In controls, relative to remitted depressed subjects, citalopram increased bilateral hippocampal responses to happy faces and increased right anterior insula response to sad faces. These findings were not accounted for by changes in BOLD responses to viewing neutral faces. These results are consistent with previous findings showing 5-HT modulation of affective processing; differences found in previously depressed participants compared with controls may contribute to emotional processing biases underlying vulnerability to depressive relapse.

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalEuropean Neuropsychopharmacology
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

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Keywords

  • Citalopram
  • FMRI
  • Face emotion processing
  • PharmacoMRI
  • Remitted depression

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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