The effect of A23187 on glucose production from methylglyoxal and pyruvate in isolated murine hepatocytes

Miklós Péter Kalapos, Pál Riba, Tam Ás Garzó, Ferenc Antoni, József Mandl

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. 1. A23187 increased the glucose production from methylglyoxal in isolated hepatocytes, and maximal stimulation was obtained at 10-6M. The effect of A23187 was dependent on the presence of Ca2+. 2. 2. Glucose production from pyruvate (less than 1 mM) in isolated hepatocytes was stimulated by A23187 in the presence of 2.5 mM Ca2+ and was depressed at pyruvate concentrations above 1 mM. Both the virtual Km and the virtual Vmax of glucose production from pyruvate were decreased by A23187.

Original languageEnglish
Pages (from-to)411-414
Number of pages4
JournalInternational Journal of Biochemistry
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 1992

ASJC Scopus subject areas

  • Biochemistry

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