The effect of a selective 5-HT2 antagonist, ketanserin, on the pulmonary responses to Escherichia coli endotoxin

H. A. Ball, J. Parratt, I. W. Rodger

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Abstract

5-Hydroxytryptamine (5-HT, 5-160 μg kg-1) injected intravenously in pentobarbitone-anaesthetized, open-chest cats caused dose-dependent increases in pulmonary arterial and intratracheal pressures. There was also a marked systemic hypotension and bradycardia. The pulmonary effects were completely prevented by ketanserin (0.2 mg kg-1), a selective 5-HT2 blocking drug. Ketanserin (0.2 mg kg-1) itself lowered arterial pressure (by 30-40 mmHg) but this systemic hypotension was relatively transient. Endotoxin (E. coli) administration resulted in pulmonary hypertension, increases in intratracheal pressure and airways resistance and reductions in lung compliance and in arterial PO2. Only the airways resistance response was modified by ketanserin (0.2 mg kg-1), suggesting a relatively unimportant role for 5-HT in mediating the acute, pulmonary effects of endotoxin in this species. The reductions in arterial (mixed venous) pH and in PO2 that resulted from endotoxin administration were not affected by pretreatment with ketanserin.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalBritish Journal of Pharmacology
Volume80
Issue number2
Publication statusPublished - 1983

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Serotonin 5-HT2 Receptor Antagonists
Ketanserin
Serotonin
Lung
Airway Resistance
Endotoxins
Hypotension
Arterial Pressure
Lung Compliance
Pentobarbital
Bradycardia
Pulmonary Hypertension
Cats
Thorax
Pressure
Escherichia coli endotoxin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

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The effect of a selective 5-HT2 antagonist, ketanserin, on the pulmonary responses to Escherichia coli endotoxin. / Ball, H. A.; Parratt, J.; Rodger, I. W.

In: British Journal of Pharmacology, Vol. 80, No. 2, 1983, p. 295-301.

Research output: Contribution to journalArticle

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