The Effect of a Progesterone‐Induced Immunologic Blocking Factor on NK‐Mediated Resorption

JULIA SZEKERES‐BARTHO, R. KINSKY, G. CHAOUAT

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

ABSTRACT: Transfer of spleen cells from poly (I)‐poly(C12U)‐treated Balb/c mice to 6.5‐days‐preg‐nant Balb/c mice significantly increased the resorption rate (P<0.01) from 11% to 48%. The supernatant of progesterone‐treated spleen cells from pregnant C3H mice abrogated the effect of spleen cell transfer. We conclude that by blocking NK activity in vivo, the progesterone‐induced blocking factor favors the maintenance of pregnancy. 1990 Munksgaard

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalAmerican Journal of Reproductive Immunology
Volume24
Issue number4
DOIs
Publication statusPublished - Dec 1990

Keywords

  • NK activity
  • Resorption
  • interferon
  • progesterone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'The Effect of a Progesterone‐Induced Immunologic Blocking Factor on NK‐Mediated Resorption'. Together they form a unique fingerprint.

  • Cite this