The effect of a progesterone-induced immunologic blocking factor on NK-mediated resorption

J. Szekeres-Barthó, R. Kinsky, G. Chaouat

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Transfer of spleen cells from poly (I)poly(C12U)-treated Balb/c mice to 6.5-days-pregnant Balb/c mice significantly increased the resorption rate (P <0.01) from 11% to 48%. The supernatant of progesterone-treated spleen cells from pregnant C3H mice abrogated the effect of spleen cell transfer. We conclude that by blocking NK activity in vivo, the progesterone-induced blocking factor favors the maintenance of pregnancy.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalAmerican Journal of Reproductive Immunology
Volume24
Issue number4
Publication statusPublished - 1990

Fingerprint

Immunologic Factors
Progesterone
Spleen
Pregnancy Maintenance
Inbred C3H Mouse
blocking factor

Keywords

  • interferon
  • NK activity
  • progesterone
  • resorption

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

The effect of a progesterone-induced immunologic blocking factor on NK-mediated resorption. / Szekeres-Barthó, J.; Kinsky, R.; Chaouat, G.

In: American Journal of Reproductive Immunology, Vol. 24, No. 4, 1990, p. 105-107.

Research output: Contribution to journalArticle

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