THE EFFECT OF A NEW ANTI‐INFLAMMATORY DRUG, FLURBIPROFEN, ON THE RESPIRATORY, HAEMODYNAMIC AND METABOLIC RESPONSES TO E. coli ENDOTOXIN SHOCK IN THE CAT

J. R. PARRATT, R. M. STURGESS

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Abstract

The intravenous administration of E. coli endotoxin (2.0 mg/kg) in cats anaesthetized with sodium pentobarbitone resulted in immediate pulmonary hypertension and reductions in lung compliance and systemic arterial Po2. These effects were abolished, or greatly reduced, by the prior intravenous administration of flurbiprofen in doses (100 and 250 μg/kg and 1.0 mg/kg) which were devoid of cardiovascular or metabolic effects. Flurbiprofen is thus the most active antipyretic‐analgesic drug so far examined in this experimental model. Production of lactate, characteristic of the severe, secondary endotoxin shock phase, was delayed only by the highest dose of flurbiprofen; hypotension, hypoglycaemia and the reduction in cardiac output which occurs during this phase, were unaffected. These findings are discussed with reference to the treatment of the ‘shocked lung’ syndrome of human septicaemia. 1976 British Pharmacological Society

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalBritish journal of pharmacology
Volume58
Issue number4
DOIs
Publication statusPublished - Dec 1976

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ASJC Scopus subject areas

  • Pharmacology

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