The antiprogestin mifepristone has shown a potential to be used as a contraceptive. Low daily doses of this drug have been shown to influence several of the local factors regarded as crucial for implantation into the human endometrium. To find out whether this regimen is sufficient to prevent pregnancy, 20 women were recruited for a study where 0,5 mg mifepriston was administered daily. A total of 91 cycles were studied. Two pregnancies occurred, which was significantly less than if no contraceptive method had been used. However, the dose chosen did not seem sufficient to act as a contraceptive although it is probably not possible to increase the dose without disturbing ovulation and bleeding pattern.
|Translated title of the contribution||The effect of a low-dose antiprogestin (RU 486) on female fertility|
|Number of pages||3|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2001|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology