A redox homeosztázis alakulása bélbetegségekben fekete retek tartalmú készítmény hatására

Translated title of the contribution: The effect of a black radish preparation on the redox homeostasis in inflammatory bowel disease

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

INTRODUCTION - Natural antioxidants have been shown to indirectly act on signal transduction pathways and influence the induction of apoptotic genes in several ways. The black radish-based granules contain several bioactive components including isothiocyanates, flavonoids, vitamins and trace elements that can modify various molecular biological pathways. The aim of this study was to find out whether this preparation has an effect on the redox homeostasis of patients with inflammatory bowel disease. PATIENTS AND METHODS - Data from 32 middle-aged patients (13 male, 19 female) with moderately active IBD were evaluated. Half of the patients (6 male, 10 female) received 0.2 g/day granules for 6 months in addition to regular treatment. Apart from other routine laboratory measurements, redox parameters including plasma reducing power, H-donor ability, free SH groups and IL-6, IL-1, TNF-alpha, bile acids, cholesterol, triglycerides, red blood cell chemiluminescence and HbA 1c level were determined. RESULTS - The black radish-based granules had no effect on the activity of inflammatory bowel disease. Beside a positive subjective judgement, bile acid levels had slightly increased and the values of redox parameters had decreased in the plasma by the end of the study period. The granules significantly diminished red blood cell chemiluminescence and moderately reduced the HbA1c-level. CONCLUSION - The results show that the granules rich in antioxidants and isothiocianate have a marked effect on the redox homeostasis of IBD patients even at low doses.

Original languageHungarian
Pages (from-to)234-240
Number of pages7
JournalLege Artis Medicinae
Volume16
Issue number3
Publication statusPublished - Mar 2006

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Raphanus
Inflammatory Bowel Diseases
Oxidation-Reduction
Homeostasis
Luminescence
Bile Acids and Salts
Antioxidants
Erythrocytes
Isothiocyanates
Interleukin-1alpha
Aptitude
Trace Elements
Flavonoids
Vitamins
Interleukin-6
Signal Transduction
Triglycerides
Tumor Necrosis Factor-alpha
Cholesterol
Tissue Donors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A redox homeosztázis alakulása bélbetegségekben fekete retek tartalmú készítmény hatására. / Blázovics, A.; Kovács, A.; Edit, Székely; Lugasi, A.

In: Lege Artis Medicinae, Vol. 16, No. 3, 03.2006, p. 234-240.

Research output: Contribution to journalArticle

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AU - Lugasi, A.

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