The effect of γ-aminobutyric acid on the potassium movements of rat cortical synaptosomes

P. V. Tozalakian, A. Csillág

Research output: Contribution to journalArticle

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Abstract

K+ fluxes of rat cortical synaptosomes were monitored by a K+ sensitive ion-selective membrane electrode. The uptake phases of K+ curves from control and experimental measurements were compared and statistically evaluated. GABA significantly reduced K+ uptake but it was able to reverse the decrease of K+ uptake caused by protoveratrine. In the absence of Ca2+ the K+ uptake was diminished; GABA had no effect on this inhibition. The effect of GABA on K+ uptake was partially reduced by bicuculline and abolished by diamino-butyric acid. The K+ content of synaptosomes decreased, while the Na+ content increased in the presence of GABA. The results are discussed in association with presynaptic depolarisation and with modulatory effects of GABA on the release of other transmitters.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalExperimental Brain Research
Volume46
Issue number1
DOIs
Publication statusPublished - Apr 1982

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Aminobutyrates
Synaptosomes
gamma-Aminobutyric Acid
Potassium
Protoveratrines
Ion-Selective Electrodes
Butyric Acid
Bicuculline
Membranes

Keywords

  • GABA
  • Potassium
  • Synaptosome

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The effect of γ-aminobutyric acid on the potassium movements of rat cortical synaptosomes. / Tozalakian, P. V.; Csillág, A.

In: Experimental Brain Research, Vol. 46, No. 1, 04.1982, p. 24-28.

Research output: Contribution to journalArticle

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