The effect of β-(Tyr9)melanotropin-(9-18) on active avoidance behavior, electroconvulsive shock-induced amnesia and T-discrimination learning of rats

G. Telegdy, L. Vécsei, Ibolya Bollók, Andrew V. Schally

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of β-(Tyr9)melanotropin-(9-18) was investigated on active avoidance behavior, electroconvulsive shock (ECS)-induced amnesia and T-discrimination learning in rats. The decapeptide inhibited the extinction of active avoidance behavior. It was also able to block ECS-induced amnesia if the treatment was performed immediately, or 4 hr or 20 hr after the ECS. In the T-discrimination paradigm the peptide facilitated spatial discrimination learning and reversal learning. These results suggest that β-(Tyr9)melanotropin-(9-18) can influence learning and memory processes in different behavioral tests.

Original languageEnglish
Pages (from-to)11-13
Number of pages3
JournalPeptides
Volume7
Issue number1
DOIs
Publication statusPublished - 1986

Fingerprint

Avoidance Learning
Melanocyte-Stimulating Hormones
Discrimination Learning
Electroshock
Amnesia
Rats
Reversal Learning
Data storage equipment
Peptides
Learning

Keywords

  • Amnesia
  • Avoidance behavior
  • T-discrimination learning
  • β-(Tyr)MSH

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

The effect of β-(Tyr9)melanotropin-(9-18) on active avoidance behavior, electroconvulsive shock-induced amnesia and T-discrimination learning of rats. / Telegdy, G.; Vécsei, L.; Bollók, Ibolya; Schally, Andrew V.

In: Peptides, Vol. 7, No. 1, 1986, p. 11-13.

Research output: Contribution to journalArticle

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