The dominant substrate of protein kinase C in the extracts of pig granulocytes is a 38 kDa Ca2+/membrane binding protein.

L. Buday, G. Farkas, A. Faragó

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the crude extracts of pig granulocytes the dominant substrate of endogenous protein kinase C was a 38 kDa protein. This protein was found in the cytosolic extract when the cells were sonicated in the presence of EGTA but it was bound to the membrane fraction when the cells were sonicated in the presence of Ca2+. The phosphorylation of the 38 kDa protein was absolutely Ca2+/phospholipid dependent. The behaviour of this protein kinase C substrate indicated that it was a lipocortin.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalActa biochimica et biophysica Hungarica
Volume24
Issue number1-2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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