The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family

J. N. Tarnay, F. Szeri, A. Iliás, T. Annilo, C. Sung, O. Le Saux, A. Váradi, M. Dean, C. D. Boyd, S. Robinow

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

ATP-binding cassette (ABC) transporters are involved in the transport of substrates across biological membranes and are essential for many cellular processes. Of the fifty-six Drosophila ABC transporter genes only white, brown, scarlet, E23 and Atet have been studied in detail. Phylogenetic analyses identify the Drosophila gene dMRP/CG6214 as an orthologue to the human multidrug-resistance associated proteins MRP1, MRP2, MRP3 and MRP6. To study evolutionarily conserved roles of MRPs we have initiated a characterization of dMRP. In situ hybridization and Northern analysis indicate that dMRP is expressed throughout development and appears to be head enriched in adults. Functional studies indicate that DMRP is capable of transporting a known MRP1 substrate and establishes DMRP as a high capacity ATP-dependent, vanadate-sensitive organic anion transporter.

Original languageEnglish
Pages (from-to)539-548
Number of pages10
JournalInsect Molecular Biology
Volume13
Issue number5
DOIs
Publication statusPublished - Oct 1 2004

Keywords

  • ABCC subfamily
  • ATP-binding cassette transporters
  • MRP
  • Membrane transporters

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Insect Science

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