The diverse functional roles and regulation of neuronal gap junctions in the retina

Stewart A. Bloomfield, B. Völgyi

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Electrical synaptic transmission through gap junctions underlies direct and rapid neuronal communication in the CNS. The diversity of functional roles that electrical synapses have is perhaps best exemplified in the vertebrate retina, in which gap junctions are formed by each of the five major neuron types. These junctions are dynamically regulated by ambient illumination and by circadian rhythms acting through light-activated neuromodulators such as dopamine and nitric oxide, which in turn activate intracellular signalling pathways in the retina.The networks formed by electrically coupled neurons are plastic and reconfigurable, and those in the retina are positioned to play key and diverse parts in the transmission and processing of visual information at every retinal level.

Original languageEnglish
Pages (from-to)495-506
Number of pages12
JournalNature Reviews Neuroscience
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Electrical Synapses
Retina
Gap Junctions
Neurons
Circadian Rhythm
Lighting
Automatic Data Processing
Synaptic Transmission
Plastics
Neurotransmitter Agents
Vertebrates
Dopamine
Nitric Oxide
Communication
Light

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The diverse functional roles and regulation of neuronal gap junctions in the retina. / Bloomfield, Stewart A.; Völgyi, B.

In: Nature Reviews Neuroscience, Vol. 10, No. 7, 07.2009, p. 495-506.

Research output: Contribution to journalArticle

@article{009becf545da4de0a9e87f0ccabf4d06,
title = "The diverse functional roles and regulation of neuronal gap junctions in the retina",
abstract = "Electrical synaptic transmission through gap junctions underlies direct and rapid neuronal communication in the CNS. The diversity of functional roles that electrical synapses have is perhaps best exemplified in the vertebrate retina, in which gap junctions are formed by each of the five major neuron types. These junctions are dynamically regulated by ambient illumination and by circadian rhythms acting through light-activated neuromodulators such as dopamine and nitric oxide, which in turn activate intracellular signalling pathways in the retina.The networks formed by electrically coupled neurons are plastic and reconfigurable, and those in the retina are positioned to play key and diverse parts in the transmission and processing of visual information at every retinal level.",
author = "Bloomfield, {Stewart A.} and B. V{\"o}lgyi",
year = "2009",
month = "7",
doi = "10.1038/nrn2636",
language = "English",
volume = "10",
pages = "495--506",
journal = "Nature Reviews Neuroscience",
issn = "1471-003X",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - The diverse functional roles and regulation of neuronal gap junctions in the retina

AU - Bloomfield, Stewart A.

AU - Völgyi, B.

PY - 2009/7

Y1 - 2009/7

N2 - Electrical synaptic transmission through gap junctions underlies direct and rapid neuronal communication in the CNS. The diversity of functional roles that electrical synapses have is perhaps best exemplified in the vertebrate retina, in which gap junctions are formed by each of the five major neuron types. These junctions are dynamically regulated by ambient illumination and by circadian rhythms acting through light-activated neuromodulators such as dopamine and nitric oxide, which in turn activate intracellular signalling pathways in the retina.The networks formed by electrically coupled neurons are plastic and reconfigurable, and those in the retina are positioned to play key and diverse parts in the transmission and processing of visual information at every retinal level.

AB - Electrical synaptic transmission through gap junctions underlies direct and rapid neuronal communication in the CNS. The diversity of functional roles that electrical synapses have is perhaps best exemplified in the vertebrate retina, in which gap junctions are formed by each of the five major neuron types. These junctions are dynamically regulated by ambient illumination and by circadian rhythms acting through light-activated neuromodulators such as dopamine and nitric oxide, which in turn activate intracellular signalling pathways in the retina.The networks formed by electrically coupled neurons are plastic and reconfigurable, and those in the retina are positioned to play key and diverse parts in the transmission and processing of visual information at every retinal level.

UR - http://www.scopus.com/inward/record.url?scp=67649476102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649476102&partnerID=8YFLogxK

U2 - 10.1038/nrn2636

DO - 10.1038/nrn2636

M3 - Article

C2 - 19491906

AN - SCOPUS:67649476102

VL - 10

SP - 495

EP - 506

JO - Nature Reviews Neuroscience

JF - Nature Reviews Neuroscience

SN - 1471-003X

IS - 7

ER -