The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate

Paulo Dinis, Ana Charrua, António Avelino, I. Nagy, José Quintas, Ulisses Ribau, Francisco Cruz

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objectives: To determine the distribution of sensory fibers immunoreactive to the pain receptor TRPV1 in the human prostate. Methods: Eight prostates were harvested from cadaver transplant donors and immediately immersion fixed. Longitudinal and transverse 20 μm sections were cut on a cryostat and immunoreacted with two anti-human TPRV1 antibodies. Results: TRPV1-immunoreactive nerve fibers were distributed throughout the prostatic urethral mucosa, verumontanum, ejaculatory ducts and periurethral prostatic acini. In the urethral mucosa, TRPV1-immunoreactive fibers penetrated the epithelial layer up to its surface. In the transitional and peripheral zones of the gland no TRPV1-immunoreactive nerve fibers were detected. Conclusions: The existence of a rich TRPV1 sensory innervation in the human prostate may open new therapeutic perspectives for the treatment of pain in patients with chronic prostatitis (Chronic Pelvic Pain Syndrome).

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalEuropean Urology
Volume48
Issue number1
DOIs
Publication statusPublished - Jul 2005

Fingerprint

TRPV Cation Channels
Prostate
Nerve Fibers
Mucous Membrane
Ejaculatory Ducts
Prostatitis
Nociceptors
Immersion
Cadaver
Tissue Donors
Pain
Antibodies
Therapeutics
TRPV1 receptor

Keywords

  • Chronic pelvic pain syndrome
  • Prostate
  • Sensory fibers
  • Vanilloid receptor

ASJC Scopus subject areas

  • Urology

Cite this

The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate. / Dinis, Paulo; Charrua, Ana; Avelino, António; Nagy, I.; Quintas, José; Ribau, Ulisses; Cruz, Francisco.

In: European Urology, Vol. 48, No. 1, 07.2005, p. 162-167.

Research output: Contribution to journalArticle

Dinis, Paulo ; Charrua, Ana ; Avelino, António ; Nagy, I. ; Quintas, José ; Ribau, Ulisses ; Cruz, Francisco. / The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate. In: European Urology. 2005 ; Vol. 48, No. 1. pp. 162-167.
@article{2152c7a61a9649f39bf235837e80cfe9,
title = "The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate",
abstract = "Objectives: To determine the distribution of sensory fibers immunoreactive to the pain receptor TRPV1 in the human prostate. Methods: Eight prostates were harvested from cadaver transplant donors and immediately immersion fixed. Longitudinal and transverse 20 μm sections were cut on a cryostat and immunoreacted with two anti-human TPRV1 antibodies. Results: TRPV1-immunoreactive nerve fibers were distributed throughout the prostatic urethral mucosa, verumontanum, ejaculatory ducts and periurethral prostatic acini. In the urethral mucosa, TRPV1-immunoreactive fibers penetrated the epithelial layer up to its surface. In the transitional and peripheral zones of the gland no TRPV1-immunoreactive nerve fibers were detected. Conclusions: The existence of a rich TRPV1 sensory innervation in the human prostate may open new therapeutic perspectives for the treatment of pain in patients with chronic prostatitis (Chronic Pelvic Pain Syndrome).",
keywords = "Chronic pelvic pain syndrome, Prostate, Sensory fibers, Vanilloid receptor",
author = "Paulo Dinis and Ana Charrua and Ant{\'o}nio Avelino and I. Nagy and Jos{\'e} Quintas and Ulisses Ribau and Francisco Cruz",
year = "2005",
month = "7",
doi = "10.1016/j.eururo.2005.01.009",
language = "English",
volume = "48",
pages = "162--167",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate

AU - Dinis, Paulo

AU - Charrua, Ana

AU - Avelino, António

AU - Nagy, I.

AU - Quintas, José

AU - Ribau, Ulisses

AU - Cruz, Francisco

PY - 2005/7

Y1 - 2005/7

N2 - Objectives: To determine the distribution of sensory fibers immunoreactive to the pain receptor TRPV1 in the human prostate. Methods: Eight prostates were harvested from cadaver transplant donors and immediately immersion fixed. Longitudinal and transverse 20 μm sections were cut on a cryostat and immunoreacted with two anti-human TPRV1 antibodies. Results: TRPV1-immunoreactive nerve fibers were distributed throughout the prostatic urethral mucosa, verumontanum, ejaculatory ducts and periurethral prostatic acini. In the urethral mucosa, TRPV1-immunoreactive fibers penetrated the epithelial layer up to its surface. In the transitional and peripheral zones of the gland no TRPV1-immunoreactive nerve fibers were detected. Conclusions: The existence of a rich TRPV1 sensory innervation in the human prostate may open new therapeutic perspectives for the treatment of pain in patients with chronic prostatitis (Chronic Pelvic Pain Syndrome).

AB - Objectives: To determine the distribution of sensory fibers immunoreactive to the pain receptor TRPV1 in the human prostate. Methods: Eight prostates were harvested from cadaver transplant donors and immediately immersion fixed. Longitudinal and transverse 20 μm sections were cut on a cryostat and immunoreacted with two anti-human TPRV1 antibodies. Results: TRPV1-immunoreactive nerve fibers were distributed throughout the prostatic urethral mucosa, verumontanum, ejaculatory ducts and periurethral prostatic acini. In the urethral mucosa, TRPV1-immunoreactive fibers penetrated the epithelial layer up to its surface. In the transitional and peripheral zones of the gland no TRPV1-immunoreactive nerve fibers were detected. Conclusions: The existence of a rich TRPV1 sensory innervation in the human prostate may open new therapeutic perspectives for the treatment of pain in patients with chronic prostatitis (Chronic Pelvic Pain Syndrome).

KW - Chronic pelvic pain syndrome

KW - Prostate

KW - Sensory fibers

KW - Vanilloid receptor

UR - http://www.scopus.com/inward/record.url?scp=20644439327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20644439327&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2005.01.009

DO - 10.1016/j.eururo.2005.01.009

M3 - Article

VL - 48

SP - 162

EP - 167

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 1

ER -