The distribution of lymphocyte subpopulations in an infant with primary intestinal lymphangiectasia.

A. Arató, E. Savilahti, L. Balogh

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Abstract

Authors analysed in an infant with primary intestinal lymphangiectasia the number of intraepithelial lymphocytes and the distribution of T lymphocyte subpopulations in the jejunal mucosa with immunohistochemical methods. It was established that the number of intraepithelial lymphocytes and of the cells belonging to the various T lymphocytes markedly decreased in the patient compared to controls, however the decrease of the CD4 cells was less than that of CD8 cells, thus the CD4/CD8 ratio increased. Authors conclude that the increase of CD4/CD8 ratio in the jejunal mucosa may explain the absence of frequent gut infections in intestinal lymphangiectasia.

Original languageEnglish
Pages (from-to)309-317
Number of pages9
JournalActa paediatrica Hungarica
Volume32
Issue number4
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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