The distribution of immunoreactive α-neo-endorphin in the central nervous system of the rat

N. Zamir, M. Palkóvits, M. J. Brownstein

Research output: Contribution to journalArticle

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Abstract

Using a specific radioimmunoassay, we have found that immunoreactive (ir) α-neo-endorphin has a widespread and unique distribution in the rat brain and spinal cord. The highest concentration in brain is in the substantia nigra (1692.1 fmol/mg of protein). Very high concentrations of ir-α-neo-endorphin (>500 fmol/mg of protein) are also found in the lateral preoptic nucleus, dentate gyrus, parabrachial nuclei, nucleus accumbens, globus pallidus, median eminence, and anterior hypothalamic nucleus. Relatively high concentrations of ir-α-neo-endorphin (250 to 500 fmol/mg of protein) are present in the bed nucleus of the stria terminalis, paraventricular nucleus, nucleus of the solitary tract, dorsomedial nucleus, central amygdaloid nucleus, periaqueductal gray matter, suprachiasmatic nucleus, periventricular nucleus, hippocampus, prepositus hypoglossal nucleus, arcuate nucleus, ventromedial nucleus, medial preoptic nucleus, zona incerta, dorsal premamillary nucleus, medial forebrain bundle (hypothalamic and preoptic), nucleus of the diagonal band, locus ceruleus, lateral septal nucleus, and nucleus ambiguus. Moderate levels (100 to 250 fmol/mg of protein) are found in the posterior hypothalamic nucleus, ventral premamillary nucleus, dorsal raphe nucleus, motor hypoglossal nucleus, caudate-putamen, periventricular thalamic nucleus, subcommissural organ, sensory trigeminal nucleus, perifornical nucleus, area postrema, supraoptic nucleus, cuneate nucleus, medial amygdaloid nucleus, and organum vasculosum laminae terminalis. Low concentrations of ir-α-neo-endorphin (

Original languageEnglish
Pages (from-to)1240-1247
Number of pages8
JournalJournal of Neuroscience
Volume4
Issue number5
Publication statusPublished - 1984

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Endorphins
Septal Nuclei
Preoptic Area
Central Nervous System
Solitary Nucleus
Proteins
Subcommissural Organ
Anterior Hypothalamic Nucleus
Medial Forebrain Bundle
Area Postrema
Trigeminal Nuclei
Ventral Thalamic Nuclei
Mediodorsal Thalamic Nucleus
Supraoptic Nucleus
Thalamic Nuclei
Periaqueductal Gray
Medulla Oblongata
Median Eminence
Arcuate Nucleus of Hypothalamus
Suprachiasmatic Nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The distribution of immunoreactive α-neo-endorphin in the central nervous system of the rat. / Zamir, N.; Palkóvits, M.; Brownstein, M. J.

In: Journal of Neuroscience, Vol. 4, No. 5, 1984, p. 1240-1247.

Research output: Contribution to journalArticle

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