The distribution of GABA and glycine response in the mouse brain using Xenopus oocytes

Atsushi Asanuma, Tetsuro Horikoshi, Keiji Yanagisawa, Kaijiro Anzai, S. Goto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Injection of mRNA from different regions of the central nervous system (CNS) of the mouse into the Xenopus oocyte caused a difference in the relative glycine to γ-aminobutyric acid (GABA) response of the oocyte. Glycine caused the response in oocytes injected with brainstem mRNA but hardly in oocytes injected with cerebrum mRNA and in oocytes injected with cerebellum mRNA. In contrast, GABA caused the response in oocytes injected with mRNA from each of the 3 parts of the CNS. These obvious regional differences may reflect the distribution of the receptors to each plausible neurotransmitter in the CNS.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalNeuroscience Letters
Volume76
Issue number1
DOIs
Publication statusPublished - Apr 23 1987

Fingerprint

Aminobutyrates
Xenopus
Glycine
Oocytes
Brain
Messenger RNA
Central Nervous System
Neurologic Mutant Mice
Cerebrum
Cerebellum
Brain Stem
Neurotransmitter Agents
Injections

Keywords

  • Distribution
  • Glycine
  • Mouse brain
  • mRNA
  • Oocyte
  • Receptor
  • γ-Aminobutyric acid (GABA)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The distribution of GABA and glycine response in the mouse brain using Xenopus oocytes. / Asanuma, Atsushi; Horikoshi, Tetsuro; Yanagisawa, Keiji; Anzai, Kaijiro; Goto, S.

In: Neuroscience Letters, Vol. 76, No. 1, 23.04.1987, p. 87-90.

Research output: Contribution to journalArticle

Asanuma, Atsushi ; Horikoshi, Tetsuro ; Yanagisawa, Keiji ; Anzai, Kaijiro ; Goto, S. / The distribution of GABA and glycine response in the mouse brain using Xenopus oocytes. In: Neuroscience Letters. 1987 ; Vol. 76, No. 1. pp. 87-90.
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