The digestable parent cyclodextrin

János Harangi, Gabriella Béke, M. Harangi, János András Mótyán

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The enzymatic digestibility of parent γ-cyclodextrin by human saliva α-amylase was investigated aiming at the determination of lifespan of intact macro ring. It was found that the ring-opening reaction was the slowest step of the γ-cyclodextrin degradation process. The reaction products were mainly maltose and malto-triose, while no higher malto-oligomers were detected. The enzymatic degradation of γ-cyclodextrin reduces the possibility of influencing bioavailability of nutritional lipophiles or drug actives co-administered with γ-cyclodextrin as an excipient or additive. Though there are numerous papers on the ring opening of cyclodextrins by amylases and the same capability of the human α-amylase is expected now we prove this activity. The hydrolysis reaction was followed by direct measurement of the resulting maltose and malto-triose, for the first time.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalJournal of Inclusion Phenomena
Volume73
Issue number1-4
DOIs
Publication statusPublished - Aug 2012

Fingerprint

cyclodextrins
Cyclodextrins
Amylases
Trioses
amylases
rings
trioses
Maltose
degradation
saliva
bioavailability
maltose
oligomers
reaction products
hydrolysis
drugs
Degradation
Excipients
enzymatic hydrolysis
Reaction products

Keywords

  • α-Amylase
  • γ-Cyclodextrin
  • Enzymatic digestion
  • HPLC
  • Malto-oligomers

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Food Science
  • Chemistry(all)

Cite this

The digestable parent cyclodextrin. / Harangi, János; Béke, Gabriella; Harangi, M.; Mótyán, János András.

In: Journal of Inclusion Phenomena, Vol. 73, No. 1-4, 08.2012, p. 335-339.

Research output: Contribution to journalArticle

Harangi, J, Béke, G, Harangi, M & Mótyán, JA 2012, 'The digestable parent cyclodextrin', Journal of Inclusion Phenomena, vol. 73, no. 1-4, pp. 335-339. https://doi.org/10.1007/s10847-011-0061-0
Harangi, János ; Béke, Gabriella ; Harangi, M. ; Mótyán, János András. / The digestable parent cyclodextrin. In: Journal of Inclusion Phenomena. 2012 ; Vol. 73, No. 1-4. pp. 335-339.
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