The different effect of alpha and gamma interferons and interleukin 2 on the expression of CD2, CD3, CD4 and CD8 antigens in comparison to histocompatibility antigens of human lymphocytes

Beatrice Kotlán, G. Böck, Éva Rajnavölgyi, M. Benczur, L. Mátyus, Éva Gyódi, Ch Huber, G. Gy Petrányi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effects of alpha- and gamma-interferons (IFN-α, -γ) and of interleukin 2 (IL-2) on the expression of certain differentiation antigens were compared with those of major histocompatibility antigens on human lymphocytes. IFN-γ and IFN-α in high doses significantly increased the expression of T11 (CD2) differentiation antigen, but did not affect the expression of T4 (CD4), T8 (CD8), T3 (CD3) and Leu-7 antigens (HNK-1). Both natural and recombinant IFN-α and -β apparently increased the expression of HLA-ABC antigens and of beta-2 microglobulin (β2m) after 16 h incubation. The amount of HLA-DR antigen, however, doubled in a few hours following IFN-γ treatment. IL-2 affected the expression of CD2 and CD8 antigens only marginally, but did not affect that of CD3 and Leu-7; however, it strongly enhanced the expression of HLA-ABC, HLA-DR. and β2m antigens. It is suggested that the expression of antigen receptor-acceptor structures on the cell membrane participates in the regulation of the immune response. Since cytokines play a significant role in this regulation, the effect of IFNs and IL-2 on the expression of various differentiation and histocompatibility antigens, demonstrated in our experiments, may lead to a better understanding of the complexity of their mechanism of action, particularly in specific and non-specific lymphocyte-mediated killing.

Original languageEnglish
Pages (from-to)259-268
Number of pages10
JournalImmunology letters
Volume18
Issue number4
DOIs
Publication statusPublished - Aug 1988

Keywords

  • Histocompatibility antigens
  • Interferon, alpha- and gamma
  • Interleukin 2, Differentiation antigens
  • antigen expression

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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