The diamide insecticide chlorantraniliprole increases the single-channel current activity of the mammalian skeletal muscle ryanodine receptor

Zsuzsanna Magyar, Gyula Diszházi, Judit Péli-Szabó, P. Szentesi, Claude Collet, L. Csernoch, P. Nánási, János Almássy

Research output: Contribution to journalArticle

Abstract

Very recently, the diamide insecticide chlorantraniliprole was shown to induce Ca 2+ -release from sarcoplasmic reticulum (SR) vesicles isolated from mammalian skeletal muscle through the activation of the SR Ca 2+ channel ryanodine receptor. As this result raises severe concerns about the safety of this chemical, we aimed to learn more about its action. To this end, single-channel analysis was performed, which showed that chlorantraniliprole induced high-activity bursts of channel opening that accounts for the Ca 2+ -releasing action described before.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalGeneral physiology and biophysics
Volume38
Issue number2
DOIs
Publication statusPublished - Jan 1 2019

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Diamide
Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
Insecticides
Skeletal Muscle
Chemical Safety
chlorantranilipole

Keywords

  • Chlorantraniliprole
  • Diamide
  • Insecticide
  • Ryanodine receptor

ASJC Scopus subject areas

  • Biophysics
  • Physiology

Cite this

The diamide insecticide chlorantraniliprole increases the single-channel current activity of the mammalian skeletal muscle ryanodine receptor. / Magyar, Zsuzsanna; Diszházi, Gyula; Péli-Szabó, Judit; Szentesi, P.; Collet, Claude; Csernoch, L.; Nánási, P.; Almássy, János.

In: General physiology and biophysics, Vol. 38, No. 2, 01.01.2019, p. 183-186.

Research output: Contribution to journalArticle

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