The development of heart failure in patients with stable angina pectoris

George C. Sutton, Jan Erik Otterstad, Bridget Anne Kirwan, Zoltán Vokó, Sophie de Brouwer, Jacobus Lubsen, Philip A. Poole-Wilson

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Abstract

Background: To describe the clinical characteristics of patients with stable angina pectoris who develop heart failure and the events preceding its onset. Methods and results: Of 7665 patients with stable angina in the ACTION trial, which compared long-acting nifedipine to placebo, 207 (2.7%) developed heart failure (HF) during a mean follow-up of 4.9 years. Those who developed HF were significantly (P < 0.05) older, more often had diabetes, had a more extensive history of cardiovascular disease, lower ejection fractions, a higher serum creatinine and glucose, a lower haemoglobin, and were more often on blood pressure lowering drugs. A cardiac event or an intervention (n = 155), a significant non-cardiac infection (n = 19) or poor control of hypertension (n = 12) preceded the development of HF in 186/207 cases (90%). There was no obvious precipitating factor in the remaining 21 patients (10%). Myocardial infarction increased the risk of the development of new HF within one week more than 100-fold. Nifedipine reduced the incidence of HF by 29% (P = 0.015). Conclusions: The development of heart failure is uncommon in patients with stable angina, and even less so in the absence of an obvious precipitating factor.

Original languageEnglish
Pages (from-to)234-242
Number of pages9
JournalEuropean journal of heart failure
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 1 2007

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Keywords

  • Angina pectoris
  • Calcium channel blockers
  • Heart failure
  • Randomised controlled trial

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sutton, G. C., Erik Otterstad, J., Kirwan, B. A., Vokó, Z., de Brouwer, S., Lubsen, J., & Poole-Wilson, P. A. (2007). The development of heart failure in patients with stable angina pectoris. European journal of heart failure, 9(3), 234-242. https://doi.org/10.1016/j.ejheart.2006.09.002