The dependence of pump-induced hyperpolarization on the tonicity of the surrounding medium and intracellular sodium concentration

M. A. Suleymanian, J. Salánki, S. N. Ayrapetyan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. 1. The dependence of pump-induced hyperpolarization of the membrane on the quantity of sodium ions injected into the cell and the tonicity of the surrounding medium was studied. 2. 2. The quantity of injected sodium ions necessary for saturation of the mechanism of active electrogenic transport varied from cell to cell ranging from 0.10 to 0.25 and from 0.18 to 0.37 nM in hypertonic and hypotonic solutions, respectively. 3. 3. At a low dose of sodium injection, much lower than the saturation region, the pump-induced hyperpolarization of the membrane was smaller in hypotonic solutions in comparison with that in hypertonic solutions. 4. 4. However, at a high dose of injected sodium ions when the mechanism of active electrogenic transport was saturated, the pump-induced hyperpolarization became larger in hypotonic solutions compared to that in hypertonic solutions.

Original languageEnglish
Pages (from-to)591-595
Number of pages5
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume78
Issue number3
DOIs
Publication statusPublished - 1984

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Hypotonic Solutions
Hypertonic Solutions
Sodium
Pumps
Active Biological Transport
Ions
Membranes
Injections

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Biochemistry

Cite this

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abstract = "1. 1. The dependence of pump-induced hyperpolarization of the membrane on the quantity of sodium ions injected into the cell and the tonicity of the surrounding medium was studied. 2. 2. The quantity of injected sodium ions necessary for saturation of the mechanism of active electrogenic transport varied from cell to cell ranging from 0.10 to 0.25 and from 0.18 to 0.37 nM in hypertonic and hypotonic solutions, respectively. 3. 3. At a low dose of sodium injection, much lower than the saturation region, the pump-induced hyperpolarization of the membrane was smaller in hypotonic solutions in comparison with that in hypertonic solutions. 4. 4. However, at a high dose of injected sodium ions when the mechanism of active electrogenic transport was saturated, the pump-induced hyperpolarization became larger in hypotonic solutions compared to that in hypertonic solutions.",
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T1 - The dependence of pump-induced hyperpolarization on the tonicity of the surrounding medium and intracellular sodium concentration

AU - Suleymanian, M. A.

AU - Salánki, J.

AU - Ayrapetyan, S. N.

PY - 1984

Y1 - 1984

N2 - 1. 1. The dependence of pump-induced hyperpolarization of the membrane on the quantity of sodium ions injected into the cell and the tonicity of the surrounding medium was studied. 2. 2. The quantity of injected sodium ions necessary for saturation of the mechanism of active electrogenic transport varied from cell to cell ranging from 0.10 to 0.25 and from 0.18 to 0.37 nM in hypertonic and hypotonic solutions, respectively. 3. 3. At a low dose of sodium injection, much lower than the saturation region, the pump-induced hyperpolarization of the membrane was smaller in hypotonic solutions in comparison with that in hypertonic solutions. 4. 4. However, at a high dose of injected sodium ions when the mechanism of active electrogenic transport was saturated, the pump-induced hyperpolarization became larger in hypotonic solutions compared to that in hypertonic solutions.

AB - 1. 1. The dependence of pump-induced hyperpolarization of the membrane on the quantity of sodium ions injected into the cell and the tonicity of the surrounding medium was studied. 2. 2. The quantity of injected sodium ions necessary for saturation of the mechanism of active electrogenic transport varied from cell to cell ranging from 0.10 to 0.25 and from 0.18 to 0.37 nM in hypertonic and hypotonic solutions, respectively. 3. 3. At a low dose of sodium injection, much lower than the saturation region, the pump-induced hyperpolarization of the membrane was smaller in hypotonic solutions in comparison with that in hypertonic solutions. 4. 4. However, at a high dose of injected sodium ions when the mechanism of active electrogenic transport was saturated, the pump-induced hyperpolarization became larger in hypotonic solutions compared to that in hypertonic solutions.

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