The degradation of Aβ25-35 by the serine protease plasmin is inhibited by aluminium

Olga V. Korchazhkina, Alison E. Ashcroft, T. Kiss, Christopher Exley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The catabolism of amyloid beta peptides (Aβ) may be important in their accumulation in the brain in both early and late-onset Alzheimer's disease (AD). The serine protease plasmin is one of a suite of proteases implicated in AD. It is a promoter of α-cleavage of the amyloid β precursor protein (AβPP) and will degrade Aβ in vitro. Herein we have demonstrated cleavage of the amyloidogenic Aβ25-35 by plasmin to produce the non-amyloidogenic fragment Aβ29-35. The activity of plasmin was halved by pre-mixing it with aluminium (Al) prior to its addition to the peptide. An interaction between Al and proteases involved in the catabolism of Aβ might define the putative link between Al and AD.

Original languageEnglish
Pages (from-to)357-367
Number of pages11
JournalJournal of Alzheimer's Disease
Volume4
Issue number5
Publication statusPublished - Oct 2002

Fingerprint

Fibrinolysin
Serine Proteases
Aluminum
Alzheimer Disease
Peptide Hydrolases
N,N-dimethyl-3,3-diphenyl-1-methylallylamine
Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Peptides
Brain

Keywords

  • Aβ catabolism
  • Aluminium
  • Alzheimer's disease
  • Amyloid
  • Plasmin
  • Urokinase plasminogen activator system

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

The degradation of Aβ25-35 by the serine protease plasmin is inhibited by aluminium. / Korchazhkina, Olga V.; Ashcroft, Alison E.; Kiss, T.; Exley, Christopher.

In: Journal of Alzheimer's Disease, Vol. 4, No. 5, 10.2002, p. 357-367.

Research output: Contribution to journalArticle

Korchazhkina, Olga V. ; Ashcroft, Alison E. ; Kiss, T. ; Exley, Christopher. / The degradation of Aβ25-35 by the serine protease plasmin is inhibited by aluminium. In: Journal of Alzheimer's Disease. 2002 ; Vol. 4, No. 5. pp. 357-367.
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