The decreased GH response to clonidine in long-term clonidine treated rats is reversed by testosterone

Thanh Kiem Do Thanh Kiem, L. Bartha, M. Gulyas, G. Makara

Research output: Contribution to journalArticle

Abstract

The injection of clonidine (31, 62 μg/kg i.p.) in intact male rats resulted in a significant increase of GH levels. In animals chronically treated with clonidine in drinking water (2 μg/ml for 14 days), acute clonidine injection was ineffective on the GH secretion at 12 or 24 hours after stopping chronic treatment. Testosterone (5 mg/kg i.m. for 4 days) in these animals markedly prevented the decrease of GH response to clonidine. The present results demonstrate that testosterone can oppose the desensitization of alpha2-adrenoceptors by the chronic clonidine treatment, at least in the case of the GH response to clonidine.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalNeuroendocrinology Letters
Volume13
Issue number2
Publication statusPublished - 1991

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Clonidine
Testosterone
Injections
Drinking Water
Adrenergic Receptors
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

The decreased GH response to clonidine in long-term clonidine treated rats is reversed by testosterone. / Do Thanh Kiem, Thanh Kiem; Bartha, L.; Gulyas, M.; Makara, G.

In: Neuroendocrinology Letters, Vol. 13, No. 2, 1991, p. 119-124.

Research output: Contribution to journalArticle

Do Thanh Kiem, Thanh Kiem ; Bartha, L. ; Gulyas, M. ; Makara, G. / The decreased GH response to clonidine in long-term clonidine treated rats is reversed by testosterone. In: Neuroendocrinology Letters. 1991 ; Vol. 13, No. 2. pp. 119-124.
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