The Cu2+ binding properties of branched peptides based on l -2,3-diaminopropionic acid

Łukasz Szyrwiel, Łukasz Szczukowski, J. Pap, Bartosz Setner, Zbigniew Szewczuk, Wiesław Malinka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Three new branched peptides, namely, H-Gly-Dap(H-Gly)-Gly-NH2 (3G), H-His-Dap(H-His)-Gly-NH2 (2HG), and H-Gly-Dap(H-Gly)-His- NH2 (2GH), where Dap stands for the 2,3-diaminopropionic acid residue, were synthesized by solid phase procedures. Because of the junction at Dap these peptides have three available pending arms for metal chelation. The complex formation between these peptides and 1 equiv of Cu2+ was investigated as a function of pH by potentiometry ultraviolet-visible absorption, circular dichroism, and X-band electron paramagnetic resonance spectroscopy in aqueous medium. Our results clearly demonstrate that cooperation between all three peptide arms essentially contributes to the stability of copper(II) complexes.

Original languageEnglish
Pages (from-to)7951-7959
Number of pages9
JournalInorganic Chemistry
Volume53
Issue number15
DOIs
Publication statusPublished - Aug 4 2014

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peptides
Peptides
acids
Potentiometry
potentiometric analysis
chelation
Electron Spin Resonance Spectroscopy
Circular Dichroism
Chelation
superhigh frequencies
dichroism
Paramagnetic resonance
solid phases
Copper
Spectrum Analysis
electron paramagnetic resonance
Metals
Spectroscopy
copper
2,3-diaminopropionic acid

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Medicine(all)

Cite this

Szyrwiel, Ł., Szczukowski, Ł., Pap, J., Setner, B., Szewczuk, Z., & Malinka, W. (2014). The Cu2+ binding properties of branched peptides based on l -2,3-diaminopropionic acid. Inorganic Chemistry, 53(15), 7951-7959. https://doi.org/10.1021/ic5007428

The Cu2+ binding properties of branched peptides based on l -2,3-diaminopropionic acid. / Szyrwiel, Łukasz; Szczukowski, Łukasz; Pap, J.; Setner, Bartosz; Szewczuk, Zbigniew; Malinka, Wiesław.

In: Inorganic Chemistry, Vol. 53, No. 15, 04.08.2014, p. 7951-7959.

Research output: Contribution to journalArticle

Szyrwiel, Ł, Szczukowski, Ł, Pap, J, Setner, B, Szewczuk, Z & Malinka, W 2014, 'The Cu2+ binding properties of branched peptides based on l -2,3-diaminopropionic acid', Inorganic Chemistry, vol. 53, no. 15, pp. 7951-7959. https://doi.org/10.1021/ic5007428
Szyrwiel, Łukasz ; Szczukowski, Łukasz ; Pap, J. ; Setner, Bartosz ; Szewczuk, Zbigniew ; Malinka, Wiesław. / The Cu2+ binding properties of branched peptides based on l -2,3-diaminopropionic acid. In: Inorganic Chemistry. 2014 ; Vol. 53, No. 15. pp. 7951-7959.
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