The crystal structures of α and β dimorphs of 1,2:5,6-dianhydrogalactitol and 3,4-di-O-acetyl-1,2:5,6-dianhydrogalactitol

Mátyás Czugler, Kálmán Simon, Laszló Institóris, Ildikó Vidra, Ingeborg Csöregh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

X-Ray crystal-structure analysis carried out on dimorphs (α and β) of the cytostatic drug 1,2:5,6-dianhydrogalactitol (DAG) and its 3,4-diacetate (DDAG) revealed conformational differences in the positioning of the oxirane termini with respect to the C-2-C-3 bond. As a consequence, the tail-to-head distances of the methylene groups at positions 1 and 6 are different in the two conformers denoted A and B (6.34 and 5.88 Å, respectively). The structures can be characterised as having conformations A in α-DAG, A,B in β-DAG, and B,B in DDAG.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalCarbohydrate Research
Volume108
Issue number2
DOIs
Publication statusPublished - Oct 16 1982

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'The crystal structures of α and β dimorphs of 1,2:5,6-dianhydrogalactitol and 3,4-di-O-acetyl-1,2:5,6-dianhydrogalactitol'. Together they form a unique fingerprint.

  • Cite this