The coronary effects of parathyroid hormone

Réka Fazekas, Pál Soós, Violetta Kékesi, Levente Fazekas, Alexander Juhász-Nagy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: The aim of the present study was to characterize the role of the ATP-sensitive potassium channels (K+ATP) in the coronary dilator action of parathyroid hormone (PTH). Methods: Dose-response curves of intracoronary administrated PTH (0.15-1.33 nmol) were obtained in control phases and during continuous intracoronary administration of the K+ ATP channel-selective antagonist glibenclamide (0.1-1.0 μmol/min) in dogs (n = 13). Results: Increments of integrated coronary conductance (excess coronary conductance) at PTH doses of 0.15 and 1.33 nmol were 1.17 versus 0.03 ml/mm Hg (p < 0.05) and 4.03 versus 0.94 ml/mm Hg (p < 0.05) in the control versus during maximal blockade, respectively. Conclusion: The results indicate that the activation of K+ATP ATP channels significantly contributes to the PTH-induced coronary vasodilation.

Original languageEnglish
Pages (from-to)234-241
Number of pages8
JournalHormone research
Volume61
Issue number5
DOIs
Publication statusPublished - Apr 27 2004

Keywords

  • ATP-sensitive potassium channel
  • Coronary circulation
  • Parathyroid hormone
  • Vasorelaxation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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