The contributions of different interneuron types to the activity patterns and plasticity of pyramidal cells in the hippocampus

Szabolcs Káli, Tamás F. Freund

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In addition to a population of pyramidal cells, area CA1 of the hippocampus contains a diverse array of inhibitory interneurons, which are believed to modulate the activity and plasticity of pyramidal neurons. Here, we describe our efforts to create simple compartmental models of two basic types of hippocampal interneuron, which target different regions of pyramidal cells. These are then used in network simulations to explore the ways in which different interneuron types modulate spiking activity, the efficacies of various sources of excitatory input, and the backpropagation of somatic action potentials into the dendrites in CA1 pyramidal cells.

Original languageEnglish
Pages (from-to)669-674
Number of pages6
JournalNeurocomputing
Volume58-60
DOIs
Publication statusPublished - Jun 1 2004

Keywords

  • Active conductances
  • Dendritic processing
  • Network model
  • Oscillations, Theta, Gamma

ASJC Scopus subject areas

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence

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