The contribution of phospholamban, a sarcoplasmic reticulum phosphoprotein, to myocardial contractility in health and disease

I. L. Grupp, E. G. Kranias, J. M. Harrer, E. Kiss, J. Slack, K. L. Koss, I. Édes, W. Luo, G. Grupp

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sarcoplasmic reticulum (SR) plays an important role in regulating myocardial contractility. The release of Ca2+ front the SR is responsible for muscle contraction, whereas resequestration of Ca2+ into the SR results in myocardial relaxation. Thus, alterations in SR function may lead to alterations in cytosolic Ca2+ handling during systolic and diastolic dysfunction of the cardiac muscle. Furthermore, abnormalities in SR proteins have been observed In certain cardiac diseases, including: ischemia, hypo- and hyperthyroid states, and heart failure. With the development of transgenic methodology in mice, it has become possible to dissect out the contribution of individual proteins in myocardial contractility; e.g., the gene of the SR phosphoprotein phospholamban could be completely deleted. The isolated work-performing heart preparation was developed to quantify contractile function in mouse hearts. Consequently, the functional changes in the Ca2+ handling of the SR produced by the absence of phospholamban can realistically be observed.

Original languageEnglish
Pages (from-to)48-61
Number of pages14
JournalHeart Failure
Volume11
Issue number2
Publication statusPublished - 1995

Fingerprint

Phosphoproteins
Sarcoplasmic Reticulum
Health
Hyperthyroidism
Muscle Contraction
phospholamban
Heart Diseases
Myocardium
Proteins
Ischemia
Heart Failure
Genes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Grupp, I. L., Kranias, E. G., Harrer, J. M., Kiss, E., Slack, J., Koss, K. L., ... Grupp, G. (1995). The contribution of phospholamban, a sarcoplasmic reticulum phosphoprotein, to myocardial contractility in health and disease. Heart Failure, 11(2), 48-61.

The contribution of phospholamban, a sarcoplasmic reticulum phosphoprotein, to myocardial contractility in health and disease. / Grupp, I. L.; Kranias, E. G.; Harrer, J. M.; Kiss, E.; Slack, J.; Koss, K. L.; Édes, I.; Luo, W.; Grupp, G.

In: Heart Failure, Vol. 11, No. 2, 1995, p. 48-61.

Research output: Contribution to journalArticle

Grupp, IL, Kranias, EG, Harrer, JM, Kiss, E, Slack, J, Koss, KL, Édes, I, Luo, W & Grupp, G 1995, 'The contribution of phospholamban, a sarcoplasmic reticulum phosphoprotein, to myocardial contractility in health and disease', Heart Failure, vol. 11, no. 2, pp. 48-61.
Grupp, I. L. ; Kranias, E. G. ; Harrer, J. M. ; Kiss, E. ; Slack, J. ; Koss, K. L. ; Édes, I. ; Luo, W. ; Grupp, G. / The contribution of phospholamban, a sarcoplasmic reticulum phosphoprotein, to myocardial contractility in health and disease. In: Heart Failure. 1995 ; Vol. 11, No. 2. pp. 48-61.
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