The constant variation: DNA methylation changes during preimplantation development

T. Arányi, András Páldi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Studies on the DNA methylation changes in the mouse preimplantation embryo suggested a simple and attractive model explaining the process believed to be general in mammals. However, recent reports revealed marked differences between different species that abrogates the universal validity of the model. In order to find an explanation to the differences, we have analyzed the published mouse data and compared them to the observations available in other species. The emerging common theme is the high variability of the methylation at all scales of observation and all levels of organization. This variability is the likely consequence of a dynamic and active redistribution process of the cytosine methylation in the genome.

Original languageEnglish
Pages (from-to)6521-6526
Number of pages6
JournalFEBS Letters
Volume580
Issue number28-29
DOIs
Publication statusPublished - Dec 11 2006

Fingerprint

Methylation
DNA Methylation
Mammals
Cytosine
Blastocyst
Genes
Observation
Genome

Keywords

  • Bisulfite treatment
  • DNA methylation
  • Early embryo
  • Epigenetic
  • Preimplantation development
  • Stochastic variation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The constant variation : DNA methylation changes during preimplantation development. / Arányi, T.; Páldi, András.

In: FEBS Letters, Vol. 580, No. 28-29, 11.12.2006, p. 6521-6526.

Research output: Contribution to journalArticle

Arányi, T. ; Páldi, András. / The constant variation : DNA methylation changes during preimplantation development. In: FEBS Letters. 2006 ; Vol. 580, No. 28-29. pp. 6521-6526.
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