The consequence of a founder effect: CCR5-Δ32, CCR2-64I and SDF1-3′A polymorphism in Vlach Gypsy population in Hungary

Emese Juhász, Judit Béres, Szilvia Kanizsai, Károly Nagy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Frequencies of genetic polymorphisms of the three most frequent HIV-1 resistance-conferring alleles playing an important role in HIV-1 pathogenesis were analysed in Vlach Gypsy populations living in Hungary, as the largest minority. Mutations in the encoding genes, such as CCR5-Δ32, CCR2-64I and SDF1-3′A are shown to result in protective effects against HIV-1 infection and disease progression. 560 samples collected from Vlach Gypsy individuals living in 6 North-East Hungarian settlements were genotyped by PCR-RFLP method. Overall allele frequencies of CCR5-Δ32, CCR2-64I and SDF1-3′A were found as 0.122, 0.186 and 0.115 respectively. All the observed genotype frequencies were in accordance with Hardy-Weinberg equilibrium. In regions, however, Vlach Gypsies live in majority and in ethnically homogenous communities, a higher CCR5-Δ32 mutations were found, with allele frequencies of 0.148 and 0.140 respectively, which are remarkably higher than those in general Hungarian people, and ten times higher than in regions of North-Western India from where present day Hungarian Gypsies originated in the Middle Ages. In the background of this higher CCR5-Δ32 allele frequency in the population analysed in our study a genetic founder effect could be assumed. Allele frequency of CCR2-64I was found to be among the highest in Europe. SDF1-3′A allele frequency in Vlach Gypsies was significantly lower than in ethnic Hungarians. 63% of the total 560 individuals tested carried at least one of the mutations studied. These results could partially explain the low incidence of HIV/AIDS among Vlach Gypsies in Hungary.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalPathology and Oncology Research
Volume18
Issue number2
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Roma
Founder Effect
Hungary
Gene Frequency
Population
HIV-1
Mutation
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
HIV Infections
Disease Progression
India
Acquired Immunodeficiency Syndrome
Alleles
Genotype
HIV
Polymerase Chain Reaction
Incidence
Genes

Keywords

  • CCR2
  • CCR5
  • Gypsy
  • HIV-1
  • Hungary
  • SDF1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

The consequence of a founder effect : CCR5-Δ32, CCR2-64I and SDF1-3′A polymorphism in Vlach Gypsy population in Hungary. / Juhász, Emese; Béres, Judit; Kanizsai, Szilvia; Nagy, Károly.

In: Pathology and Oncology Research, Vol. 18, No. 2, 04.2012, p. 177-182.

Research output: Contribution to journalArticle

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