The concept of internal solubilization in peptide synthesis: ethylene glycol-based protecting groups

László Kocsis, Thomas Bruckdorfer, György Orosz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A novel, ethylene glycol-based protecting group is designed and synthesized for use in solid phase peptide synthesis. Ether and ester type protected amino acids are prepared. The acid stability of the new protecting group showed complete Fmoc/t-Bu compatibility. The new derivatives are tested in solid phase peptide synthesis, with a 'difficult' sequence to examine the disruption of peptide aggregation.

Original languageEnglish
Pages (from-to)7015-7017
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number49
DOIs
Publication statusPublished - Dec 1 2008

Keywords

  • Aggregation
  • Amino acid
  • PEG
  • Peptide
  • Protecting group
  • SPSS
  • Solubility

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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