The comprehensive acid-base characterization of glutathione

Arash Mirzahosseini, Máté Somlyay, B. Noszál

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Glutathione in its thiol (GSH) and disulfide (GSSG) forms, and 4 related compounds were studied by 1H NMR-pH titrations and a case-tailored evaluation method. The resulting acid-base properties are quantified in terms of 128 microscopic protonation constants; the first complete set of such parameters for this vitally important pair of compounds. The concomitant 12 interactivity parameters were also determined. Since biological redox systems are regularly compared to the GSH-GSSG pair, the eight microscopic thiolate basicities determined this way are exclusive means for assessing subtle redox parameters in a wide pH range.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalChemical Physics Letters
Volume622
DOIs
Publication statusPublished - Feb 16 2015

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glutathione
Glutathione Disulfide
Glutathione
acids
Acids
Protonation
Alkalinity
Titration
Sulfhydryl Compounds
Disulfides
Nuclear magnetic resonance
disulfides
thiols
titration
nuclear magnetic resonance
evaluation
Oxidation-Reduction

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Physics and Astronomy(all)

Cite this

The comprehensive acid-base characterization of glutathione. / Mirzahosseini, Arash; Somlyay, Máté; Noszál, B.

In: Chemical Physics Letters, Vol. 622, 16.02.2015, p. 50-56.

Research output: Contribution to journalArticle

Mirzahosseini, Arash ; Somlyay, Máté ; Noszál, B. / The comprehensive acid-base characterization of glutathione. In: Chemical Physics Letters. 2015 ; Vol. 622. pp. 50-56.
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