Abstract
Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 261-269 |
| Number of pages | 9 |
| Journal | Scandinavian Journal of Immunology |
| Volume | 68 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2008 |
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ASJC Scopus subject areas
- Immunology
Cite this
The complex role of vitamin D in autoimmune diseases. / Szodoray, P.; Nakken, B.; Gaál, J.; Jonsson, R.; Szegedi, A.; Zold, E.; Szegedi, G.; Brun, J. G.; Gesztelyi, R.; Zeher, M.; Bodolay, E.
In: Scandinavian Journal of Immunology, Vol. 68, No. 3, 09.2008, p. 261-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The complex role of vitamin D in autoimmune diseases
AU - Szodoray, P.
AU - Nakken, B.
AU - Gaál, J.
AU - Jonsson, R.
AU - Szegedi, A.
AU - Zold, E.
AU - Szegedi, G.
AU - Brun, J. G.
AU - Gesztelyi, R.
AU - Zeher, M.
AU - Bodolay, E.
PY - 2008/9
Y1 - 2008/9
N2 - Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases.
AB - Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=48749115601&partnerID=8YFLogxK
U2 - 10.1111/j.1365-3083.2008.02127.x
DO - 10.1111/j.1365-3083.2008.02127.x
M3 - Article
C2 - 18510590
AN - SCOPUS:48749115601
VL - 68
SP - 261
EP - 269
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
SN - 0300-9475
IS - 3
ER -