The complete microspeciation of arginine and citrulline

Gábor Orgován, Béla Noszál

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

1H NMR-pH titrations of arginine, the most basic natural amino acid and citrulline, its neutral counterpart were carried out. Two other closely related auxiliary compounds were also studied. The 8 macroscopic protonation constants were determined. Combining the four datasets in a deductive method, all the 12 microconstants of arginine, the 4 microconstants of citrulline and arginine amide were calculated. An error-propagation analysis and the pH-dependent distribution of the 8 arginine microspecies are provided.

Original languageEnglish
Pages (from-to)965-971
Number of pages7
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume54
Issue number5
DOIs
Publication statusPublished - Apr 5 2011

Keywords

  • Arginine
  • Citrulline
  • Highly basic media
  • Microscopic acid-base properties
  • Microspeciation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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