The combination of homozygous MTHFR 677T and angiotensin II type-1 receptor 1166C variants confers the risk of small-vessel-associated ischemic stroke

Z. Szolnoki, A. Maász, L. Magyari, Katalin Horvatovich, Bernadett Farago, F. Somogyvári, A. Kondacs, M. Szabó, Anita Bodor, Ferenc Hadarits, B. Melegh

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8 Citations (Scopus)

Abstract

Previous studies have suggested that both angiotensin II type-1 receptor (AT1R) 1166C and methylenetetrahydrofolate reductase (MTHFR) 677T variants can have disadvantageous effects on the small-vessel circulation under certain conditions. The purpose of this study was to analyze the possible consequences of the simultaneous distribution of these two genetic variants in different types of ischemic stroke. The genetic and clinical data on 357 ischemic stroke patients and 263 control subjects were analyzed by using univariate and logistic statistical approaches. Neither the MTHFR677T nor the AT1R 1166C genetic variant alone conferred the risk of any subtype of ischemic stroke. The combination of the homozygous MTHFR 677TT genotype and at least one AT1R 1166C allele occurred more frequently in the ischemic stroke patients (8.68%) than in the controls (4.56%, p

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalJournal of Molecular Neuroscience
Volume31
Issue number3
Publication statusPublished - Mar 2007

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Methylenetetrahydrofolate Reductase (NADPH2)
Angiotensin Type 1 Receptor
Stroke
Logistics
Alleles
Genotype

Keywords

  • Angiotensin II
  • AT1R 1166C
  • Cerebral infarction
  • MTHFR C677T
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry
  • Genetics

Cite this

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title = "The combination of homozygous MTHFR 677T and angiotensin II type-1 receptor 1166C variants confers the risk of small-vessel-associated ischemic stroke",
abstract = "Previous studies have suggested that both angiotensin II type-1 receptor (AT1R) 1166C and methylenetetrahydrofolate reductase (MTHFR) 677T variants can have disadvantageous effects on the small-vessel circulation under certain conditions. The purpose of this study was to analyze the possible consequences of the simultaneous distribution of these two genetic variants in different types of ischemic stroke. The genetic and clinical data on 357 ischemic stroke patients and 263 control subjects were analyzed by using univariate and logistic statistical approaches. Neither the MTHFR677T nor the AT1R 1166C genetic variant alone conferred the risk of any subtype of ischemic stroke. The combination of the homozygous MTHFR 677TT genotype and at least one AT1R 1166C allele occurred more frequently in the ischemic stroke patients (8.68{\%}) than in the controls (4.56{\%}, p",
keywords = "Angiotensin II, AT1R 1166C, Cerebral infarction, MTHFR C677T, Stroke",
author = "Z. Szolnoki and A. Ma{\'a}sz and L. Magyari and Katalin Horvatovich and Bernadett Farago and F. Somogyv{\'a}ri and A. Kondacs and M. Szab{\'o} and Anita Bodor and Ferenc Hadarits and B. Melegh",
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AU - Szolnoki, Z.

AU - Maász, A.

AU - Magyari, L.

AU - Horvatovich, Katalin

AU - Farago, Bernadett

AU - Somogyvári, F.

AU - Kondacs, A.

AU - Szabó, M.

AU - Bodor, Anita

AU - Hadarits, Ferenc

AU - Melegh, B.

PY - 2007/3

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AB - Previous studies have suggested that both angiotensin II type-1 receptor (AT1R) 1166C and methylenetetrahydrofolate reductase (MTHFR) 677T variants can have disadvantageous effects on the small-vessel circulation under certain conditions. The purpose of this study was to analyze the possible consequences of the simultaneous distribution of these two genetic variants in different types of ischemic stroke. The genetic and clinical data on 357 ischemic stroke patients and 263 control subjects were analyzed by using univariate and logistic statistical approaches. Neither the MTHFR677T nor the AT1R 1166C genetic variant alone conferred the risk of any subtype of ischemic stroke. The combination of the homozygous MTHFR 677TT genotype and at least one AT1R 1166C allele occurred more frequently in the ischemic stroke patients (8.68%) than in the controls (4.56%, p

KW - Angiotensin II

KW - AT1R 1166C

KW - Cerebral infarction

KW - MTHFR C677T

KW - Stroke

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