The clinical cooperative trial guide to a critical approach

Ch B. Ostertag, D. Werdier, J. Barcia, A. Booth, B. Cucciniello, V. Fasano, J. J.A. Mooij, J. P. Sichez, F. Silva-Santos, J. Vajda

Research output: Contribution to journalArticle

Abstract

The growing difference with regard to academic and professional accountability between neurosurgeons and neuroscience is alarming. Controlled clinical trials continue to be the most scientifically valid method of evaluating standard treatments against the risks and benefits of medical innovations. Clinical research becomes more rewarding as neurosurgeons gain familiarity with the particulars of the structure and relevance of expertly designed clinical cooperative trials. The basic principles and the significance of biometrical essentials (research hypothesis, comparability, randomized and nonrandomized trials, phases of studies and planning steps) are briefly discussed. A guide to the pertinent literature is provided.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalActa neurochirurgica
Volume110
Issue number1-2
DOIs
Publication statusPublished - Mar 1 1991

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Keywords

  • Clinical trial
  • controlled trial
  • cooperative trial
  • design

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Ostertag, C. B., Werdier, D., Barcia, J., Booth, A., Cucciniello, B., Fasano, V., Mooij, J. J. A., Sichez, J. P., Silva-Santos, F., & Vajda, J. (1991). The clinical cooperative trial guide to a critical approach. Acta neurochirurgica, 110(1-2), 1-5. https://doi.org/10.1007/BF01402040