The clear and dark sides of water: Influence on the coiled coil folding domain

Tamás Vajda, A. Perczel

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The essential role of water in extra- and intracellular coiled coil structures of proteins is critically evaluated, and the different protein types incorporating coiled coil units are overviewed. The following subjects are discussed: i) influence of water on the formation and degradation of the coiled coil domain together with the stability of this conformer type; ii) the water's paradox iii) design of coiled coil motifs and iv) expert opinion and outlook is presented. The clear and dark sides refer to the positive and negative aspects of the water molecule, as it may enhance or inhibit a given folding event. This duplicity can be symbolized by the Roman 'Janus-face' which means that water may facilitate and stimulate coiled coil structure formation, however, it may contribute to the fatal processes of oligomerization and amyloidosis of the very same polypeptide chain.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalBiomolecular Concepts
Volume7
Issue number3
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Water
Oligomerization
Expert Testimony
Amyloidosis
Proteins
Degradation
Peptides
Molecules

Keywords

  • coiled coil folding
  • degradation
  • influence of water
  • molecular design
  • stability

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience

Cite this

The clear and dark sides of water : Influence on the coiled coil folding domain. / Vajda, Tamás; Perczel, A.

In: Biomolecular Concepts, Vol. 7, No. 3, 01.06.2016, p. 189-195.

Research output: Contribution to journalReview article

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