The cholinergic system in alzheimer's disease

P. Kása, Zoltan Rakonczay, K. Gulya

Research output: Contribution to journalArticle

325 Citations (Scopus)

Abstract

The past decade has witnessed an enormous increase in our knowledge of the variety and complexity of neuropathological and neurochemical changes in Alzheimer's disease. Although the disease is characterized by multiple deficits of neurotransmitters in the brain, this overview emphasizes the structural and neurochemical localization of the elements of the acetylcholine system (choline acetyl-transferase, acetylcholinesterase, and muscarinic and nicotinic acetylcholine receptors) in the non-demented brain and in Alzheimer's disease brain samples. The results demonstrate a great variation in the distribution of acetylcholinesterase, choline acetyltransferase, and the nicotinic and muscarinic acetyl-choline receptors in the different brain areas, nuclei and subnuclei. When stratification is present in certain brain regions (olfactory bulb, cortex, hippocampus, etc.), differences can be detected as regards the laminar distribution of the elements of the acetylcholine system. Alzheimer's disease involves a substantial loss of the elements of the cholinergic system. There is evidence that the most affected areas include the cortex, the entorhinal area, the hippocampus, the ventral striatum and the basal part of the forebrain. Other brain areas are less affected. The fact that the acetyl-choline system, which plays a significant role in the memory function, is seriously impaired in Alzheimer's disease has accelerated work on the development of new drugs for treatment of the disease of the 20th century.

Original languageEnglish
Pages (from-to)511-535
Number of pages25
JournalProgress in Neurobiology
Volume52
Issue number6
DOIs
Publication statusPublished - Aug 1997

Fingerprint

Cholinergic Agents
Alzheimer Disease
Brain
Choline
Acetylcholinesterase
Acetylcholine
Hippocampus
Entorhinal Cortex
Choline O-Acetyltransferase
Olfactory Bulb
Nicotinic Receptors
Muscarinic Receptors
Transferases
Neurotransmitter Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The cholinergic system in alzheimer's disease. / Kása, P.; Rakonczay, Zoltan; Gulya, K.

In: Progress in Neurobiology, Vol. 52, No. 6, 08.1997, p. 511-535.

Research output: Contribution to journalArticle

Kása, P. ; Rakonczay, Zoltan ; Gulya, K. / The cholinergic system in alzheimer's disease. In: Progress in Neurobiology. 1997 ; Vol. 52, No. 6. pp. 511-535.
@article{1ec627cd46104b6e8f5dfd1192edeefe,
title = "The cholinergic system in alzheimer's disease",
abstract = "The past decade has witnessed an enormous increase in our knowledge of the variety and complexity of neuropathological and neurochemical changes in Alzheimer's disease. Although the disease is characterized by multiple deficits of neurotransmitters in the brain, this overview emphasizes the structural and neurochemical localization of the elements of the acetylcholine system (choline acetyl-transferase, acetylcholinesterase, and muscarinic and nicotinic acetylcholine receptors) in the non-demented brain and in Alzheimer's disease brain samples. The results demonstrate a great variation in the distribution of acetylcholinesterase, choline acetyltransferase, and the nicotinic and muscarinic acetyl-choline receptors in the different brain areas, nuclei and subnuclei. When stratification is present in certain brain regions (olfactory bulb, cortex, hippocampus, etc.), differences can be detected as regards the laminar distribution of the elements of the acetylcholine system. Alzheimer's disease involves a substantial loss of the elements of the cholinergic system. There is evidence that the most affected areas include the cortex, the entorhinal area, the hippocampus, the ventral striatum and the basal part of the forebrain. Other brain areas are less affected. The fact that the acetyl-choline system, which plays a significant role in the memory function, is seriously impaired in Alzheimer's disease has accelerated work on the development of new drugs for treatment of the disease of the 20th century.",
author = "P. K{\'a}sa and Zoltan Rakonczay and K. Gulya",
year = "1997",
month = "8",
doi = "10.1016/S0301-0082(97)00028-2",
language = "English",
volume = "52",
pages = "511--535",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - The cholinergic system in alzheimer's disease

AU - Kása, P.

AU - Rakonczay, Zoltan

AU - Gulya, K.

PY - 1997/8

Y1 - 1997/8

N2 - The past decade has witnessed an enormous increase in our knowledge of the variety and complexity of neuropathological and neurochemical changes in Alzheimer's disease. Although the disease is characterized by multiple deficits of neurotransmitters in the brain, this overview emphasizes the structural and neurochemical localization of the elements of the acetylcholine system (choline acetyl-transferase, acetylcholinesterase, and muscarinic and nicotinic acetylcholine receptors) in the non-demented brain and in Alzheimer's disease brain samples. The results demonstrate a great variation in the distribution of acetylcholinesterase, choline acetyltransferase, and the nicotinic and muscarinic acetyl-choline receptors in the different brain areas, nuclei and subnuclei. When stratification is present in certain brain regions (olfactory bulb, cortex, hippocampus, etc.), differences can be detected as regards the laminar distribution of the elements of the acetylcholine system. Alzheimer's disease involves a substantial loss of the elements of the cholinergic system. There is evidence that the most affected areas include the cortex, the entorhinal area, the hippocampus, the ventral striatum and the basal part of the forebrain. Other brain areas are less affected. The fact that the acetyl-choline system, which plays a significant role in the memory function, is seriously impaired in Alzheimer's disease has accelerated work on the development of new drugs for treatment of the disease of the 20th century.

AB - The past decade has witnessed an enormous increase in our knowledge of the variety and complexity of neuropathological and neurochemical changes in Alzheimer's disease. Although the disease is characterized by multiple deficits of neurotransmitters in the brain, this overview emphasizes the structural and neurochemical localization of the elements of the acetylcholine system (choline acetyl-transferase, acetylcholinesterase, and muscarinic and nicotinic acetylcholine receptors) in the non-demented brain and in Alzheimer's disease brain samples. The results demonstrate a great variation in the distribution of acetylcholinesterase, choline acetyltransferase, and the nicotinic and muscarinic acetyl-choline receptors in the different brain areas, nuclei and subnuclei. When stratification is present in certain brain regions (olfactory bulb, cortex, hippocampus, etc.), differences can be detected as regards the laminar distribution of the elements of the acetylcholine system. Alzheimer's disease involves a substantial loss of the elements of the cholinergic system. There is evidence that the most affected areas include the cortex, the entorhinal area, the hippocampus, the ventral striatum and the basal part of the forebrain. Other brain areas are less affected. The fact that the acetyl-choline system, which plays a significant role in the memory function, is seriously impaired in Alzheimer's disease has accelerated work on the development of new drugs for treatment of the disease of the 20th century.

UR - http://www.scopus.com/inward/record.url?scp=0030767243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030767243&partnerID=8YFLogxK

U2 - 10.1016/S0301-0082(97)00028-2

DO - 10.1016/S0301-0082(97)00028-2

M3 - Article

C2 - 9316159

AN - SCOPUS:0030767243

VL - 52

SP - 511

EP - 535

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

IS - 6

ER -