The chemistry of 2-aminocyclopentanecarboxylic acid

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41 Citations (Scopus)

Abstract

The syntheses, transformations and some of the biological features of 2- aminocyclopentanecarboxylic acid are reviewed. The (1S,2R) enantiomer (cispentacin) was recently isolated from different natural sources. cis-2-Aminocyclopentacecarboxylic acid is also a component of the antibiotic amipurimycin. The paper discusses the syntheses of the racemic compounds, resolutions of the racemates and enetioselective syntheses of the title compounds. The transformations to heterocyclic compounds, applications in peptide syntheses, and biological effects are reviewed.

Original languageEnglish
Title of host publicationStudies in Natural Products Chemistry
PublisherElsevier
Pages273-306
Number of pages34
EditionPART C
DOIs
Publication statusPublished - 2000

Publication series

NameStudies in Natural Products Chemistry
NumberPART C
Volume22
ISSN (Print)1572-5995

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ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry

Cite this

Fülöp, F. (2000). The chemistry of 2-aminocyclopentanecarboxylic acid. In Studies in Natural Products Chemistry (PART C ed., pp. 273-306). (Studies in Natural Products Chemistry; Vol. 22, No. PART C). Elsevier. https://doi.org/10.1016/S1572-5995(00)80028-9